---
res:
  bibo_abstract:
  - Cells are arranged into species-specific patterns during early embryogenesis.
    Such cell division patterns are important since they often reflect the distribution
    of localized cortical factors from eggs/fertilized eggs to specific cells as well
    as the emergence of organismal form. However, it has proven difficult to reveal
    the mechanisms that underlie the emergence of cell positioning patterns that underlie
    embryonic shape, likely because a systems-level approach is required that integrates
    cell biological, genetic, developmental, and mechanical parameters. The choice
    of organism to address such questions is also important. Because ascidians display
    the most extreme form of invariant cleavage pattern among the metazoans, we have
    been analyzing the cell biological mechanisms that underpin three aspects of cell
    division (unequal cell division (UCD), oriented cell division (OCD), and asynchronous
    cell cycles) which affect the overall shape of the blastula-stage ascidian embryo
    composed of 64 cells. In ascidians, UCD creates two small cells at the 16-cell
    stage that in turn undergo two further successive rounds of UCD. Starting at the
    16-cell stage, the cell cycle becomes asynchronous, whereby the vegetal half divides
    before the animal half, thus creating 24-, 32-, 44-, and then 64-cell stages.
    Perturbing either UCD or the alternate cell division rhythm perturbs cell position.
    We propose that dynamic cell shape changes propagate throughout the embryo via
    cell-cell contacts to create the ascidian-specific invariant cleavage pattern.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Alex
      foaf_name: McDougall, Alex
      foaf_surname: McDougall
  - foaf_Person:
      foaf_givenName: Janet
      foaf_name: Chenevert, Janet
      foaf_surname: Chenevert
  - foaf_Person:
      foaf_givenName: Benoit G
      foaf_name: Godard, Benoit G
      foaf_surname: Godard
      foaf_workInfoHomepage: http://www.librecat.org/personId=33280250-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Remi
      foaf_name: Dumollard, Remi
      foaf_surname: Dumollard
  bibo_doi: 10.1007/978-3-030-23459-1_6
  bibo_volume: 68
  dct_date: 2019^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0080-1844
  - http://id.crossref.org/issn/1861-0412
  - http://id.crossref.org/issn/9783030234584
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Emergence of embryo shape during cleavage divisions@
  fabio_hasPubmedId: '31598855'
...