---
res:
  bibo_abstract:
  - 'How the organization of genes on a chromosome shapes adaptation is essential
    for understanding evolutionary paths. Here, we investigate how adaptation to rapidly
    increasing levels of antibiotic depends on the chromosomal neighborhood of a drug-resistance
    gene inserted at different positions of the Escherichia coli chromosome. Using
    a dual-fluorescence reporter that allows us to distinguish gene amplifications
    from other up-mutations, we track in real-time adaptive changes in expression
    of the drug-resistance gene. We find that the relative contribution of several
    mutation types differs systematically between loci due to properties of neighboring
    genes: essentiality, expression, orientation, termination, and presence of duplicates.
    These properties determine rate and fitness effects of gene amplification, deletions,
    and mutations compromising transcriptional termination. Thus, the adaptive potential
    of a gene under selection is a system-property with a complex genetic basis that
    is specific for each chromosomal locus, and it can be inferred from detailed functional
    and genomic data.@eng'
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Magdalena
      foaf_name: Steinrück, Magdalena
      foaf_surname: Steinrück
      foaf_workInfoHomepage: http://www.librecat.org/personId=2C023F40-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1229-9719
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  bibo_doi: 10.7554/eLife.25100
  bibo_volume: 6
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000406183700001
  dct_isPartOf:
  - http://id.crossref.org/issn/2050-084X
  dct_language: eng
  dct_publisher: eLife Sciences Publications@
  dct_title: Complex chromosomal neighborhood effects determine the adaptive potential
    of a gene under selection@
...