---
res:
  bibo_abstract:
  - BAX, a member of the BCL2 gene family, controls the committed step of the intrinsic
    apoptotic program. Mitochondrial fragmentation is a commonly observed feature
    of apoptosis, which occurs through the process of mitochondrial fission. BAX has
    consistently been associated with mitochondrial fission, yet how BAX participates
    in the process of mitochondrial fragmentation during apoptosis remains to be tested.
    Time-lapse imaging of BAX recruitment and mitochondrial fragmentation demonstrates
    that rapid mitochondrial fragmentation during apoptosis occurs after the complete
    recruitment of BAX to the mitochondrial outer membrane (MOM). The requirement
    of a fully functioning BAX protein for the fission process was demonstrated further
    in BAX/BAK-deficient HCT116 cells expressing a P168A mutant of BAX. The mutant
    performed fusion to restore the mitochondrial network. but was not demonstrably
    recruited to the MOM after apoptosis induction. Under these conditions, mitochondrial
    fragmentation was blocked. Additionally, we show that loss of the fission protein,
    dynamin-like protein 1 (DRP1), does not temporally affect the initiation time
    or rate of BAX recruitment, but does reduce the final level of BAX recruited to
    the MOM during the late phase of BAX recruitment. These correlative observations
    suggest a model where late-stage BAX oligomers play a functional part of the mitochondrial
    fragmentation machinery in apoptotic cells.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Margaret E
      foaf_name: Maes, Margaret E
      foaf_surname: Maes
      foaf_workInfoHomepage: http://www.librecat.org/personId=3838F452-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-9642-1085
  - foaf_Person:
      foaf_givenName: J. A.
      foaf_name: Grosser, J. A.
      foaf_surname: Grosser
  - foaf_Person:
      foaf_givenName: R. L.
      foaf_name: Fehrman, R. L.
      foaf_surname: Fehrman
  - foaf_Person:
      foaf_givenName: C. L.
      foaf_name: Schlamp, C. L.
      foaf_surname: Schlamp
  - foaf_Person:
      foaf_givenName: R. W.
      foaf_name: Nickells, R. W.
      foaf_surname: Nickells
  bibo_doi: 10.1038/s41598-019-53049-w
  bibo_volume: 9
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000495857600019
  dct_isPartOf:
  - http://id.crossref.org/issn/2045-2322
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Completion of BAX recruitment correlates with mitochondrial fission during
    apoptosis@
  fabio_hasPubmedId: '31719602'
...