Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture Wang, Jilin W. J. L. Lombardi, Fabrizio ; https://orcid.org/0000-0003-2623-5249 Zhang, Xiyun Anaclet, Christelle Ivanov, Plamen Ch. ddc:570 ddc:000 Origin and functions of intermittent transitions among sleep stages, including short awakenings and arousals, constitute a challenge to the current homeostatic framework for sleep regulation, focusing on factors modulating sleep over large time scales. Here we propose that the complex micro-architecture characterizing the sleep-wake cycle results from an underlying non-equilibrium critical dynamics, bridging collective behaviors across spatio-temporal scales. We investigate θ and δ wave dynamics in control rats and in rats with lesions of sleep-promoting neurons in the parafacial zone. We demonstrate that intermittent bursts in θ and δ rhythms exhibit a complex temporal organization, with long-range power-law correlations and a robust duality of power law (θ-bursts, active phase) and exponential-like (δ-bursts, quiescent phase) duration distributions, typical features of non-equilibrium systems self-organizing at criticality. Crucially, such temporal organization relates to anti-correlated coupling between θ- and δ-bursts, and is independent of the dominant physiologic state and lesions, a solid indication of a basic principle in sleep dynamics. Public Library of Science 2019 info:eu-repo/semantics/article doc-type:Article Article http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/7103 https://research-explorer.ista.ac.at/download/7103/7104 Wang JWJL, Lombardi F, Zhang X, Anaclet C, Ivanov PC. Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and wake micro-architecture. <i>PLoS Computational Biology</i>. 2019;15(11). doi:<a href="https://doi.org/10.1371/journal.pcbi.1007268">10.1371/journal.pcbi.1007268</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pcbi.1007268 info:eu-repo/semantics/altIdentifier/issn/1553-7358 info:eu-repo/semantics/altIdentifier/wos/000500976100014 info:eu-repo/semantics/altIdentifier/pmid/31725712 info:eu-repo/semantics/openAccess