---
_id: '7103'
abstract:
- lang: eng
  text: Origin and functions of intermittent transitions among sleep stages, including
    short awakenings and arousals, constitute a challenge to the current homeostatic
    framework for sleep regulation, focusing on factors modulating sleep over large
    time scales. Here we propose that the complex micro-architecture characterizing
    the sleep-wake cycle results from an underlying non-equilibrium critical dynamics,
    bridging collective behaviors across spatio-temporal scales. We investigate θ
    and δ wave dynamics in control rats and in rats with lesions of sleep-promoting
    neurons in the parafacial zone. We demonstrate that intermittent bursts in θ and
    δ rhythms exhibit a complex temporal organization, with long-range power-law correlations
    and a robust duality of power law (θ-bursts, active phase) and exponential-like
    (δ-bursts, quiescent phase) duration distributions, typical features of non-equilibrium
    systems self-organizing at criticality. Crucially, such temporal organization
    relates to anti-correlated coupling between θ- and δ-bursts, and is independent
    of the dominant physiologic state and lesions, a solid indication of a basic principle
    in sleep dynamics.
article_number: e1007268
article_processing_charge: No
article_type: original
author:
- first_name: Jilin W. J. L.
  full_name: Wang, Jilin W. J. L.
  last_name: Wang
- first_name: Fabrizio
  full_name: Lombardi, Fabrizio
  id: A057D288-3E88-11E9-986D-0CF4E5697425
  last_name: Lombardi
  orcid: 0000-0003-2623-5249
- first_name: Xiyun
  full_name: Zhang, Xiyun
  last_name: Zhang
- first_name: Christelle
  full_name: Anaclet, Christelle
  last_name: Anaclet
- first_name: Plamen Ch.
  full_name: Ivanov, Plamen Ch.
  last_name: Ivanov
citation:
  ama: Wang JWJL, Lombardi F, Zhang X, Anaclet C, Ivanov PC. Non-equilibrium critical
    dynamics of bursts in θ and δ rhythms as fundamental characteristic of sleep and
    wake micro-architecture. <i>PLoS Computational Biology</i>. 2019;15(11). doi:<a
    href="https://doi.org/10.1371/journal.pcbi.1007268">10.1371/journal.pcbi.1007268</a>
  apa: Wang, J. W. J. L., Lombardi, F., Zhang, X., Anaclet, C., &#38; Ivanov, P. C.
    (2019). Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental
    characteristic of sleep and wake micro-architecture. <i>PLoS Computational Biology</i>.
    Public Library of Science. <a href="https://doi.org/10.1371/journal.pcbi.1007268">https://doi.org/10.1371/journal.pcbi.1007268</a>
  chicago: Wang, Jilin W. J. L., Fabrizio Lombardi, Xiyun Zhang, Christelle Anaclet,
    and Plamen Ch. Ivanov. “Non-Equilibrium Critical Dynamics of Bursts in θ and δ
    Rhythms as Fundamental Characteristic of Sleep and Wake Micro-Architecture.” <i>PLoS
    Computational Biology</i>. Public Library of Science, 2019. <a href="https://doi.org/10.1371/journal.pcbi.1007268">https://doi.org/10.1371/journal.pcbi.1007268</a>.
  ieee: J. W. J. L. Wang, F. Lombardi, X. Zhang, C. Anaclet, and P. C. Ivanov, “Non-equilibrium
    critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of
    sleep and wake micro-architecture,” <i>PLoS Computational Biology</i>, vol. 15,
    no. 11. Public Library of Science, 2019.
  ista: Wang JWJL, Lombardi F, Zhang X, Anaclet C, Ivanov PC. 2019. Non-equilibrium
    critical dynamics of bursts in θ and δ rhythms as fundamental characteristic of
    sleep and wake micro-architecture. PLoS Computational Biology. 15(11), e1007268.
  mla: Wang, Jilin W. J. L., et al. “Non-Equilibrium Critical Dynamics of Bursts in
    θ and δ Rhythms as Fundamental Characteristic of Sleep and Wake Micro-Architecture.”
    <i>PLoS Computational Biology</i>, vol. 15, no. 11, e1007268, Public Library of
    Science, 2019, doi:<a href="https://doi.org/10.1371/journal.pcbi.1007268">10.1371/journal.pcbi.1007268</a>.
  short: J.W.J.L. Wang, F. Lombardi, X. Zhang, C. Anaclet, P.C. Ivanov, PLoS Computational
    Biology 15 (2019).
date_created: 2019-11-25T08:20:47Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2025-04-14T07:44:06Z
day: '01'
ddc:
- '570'
- '000'
department:
- _id: GaTk
doi: 10.1371/journal.pcbi.1007268
ec_funded: 1
external_id:
  isi:
  - '000500976100014'
  pmid:
  - '31725712'
file:
- access_level: open_access
  checksum: 2a096a9c6dcc6eaa94077b2603bc6c12
  content_type: application/pdf
  creator: dernst
  date_created: 2019-11-25T08:24:01Z
  date_updated: 2020-07-14T12:47:49Z
  file_id: '7104'
  file_name: 2019_PLOSComBio_Wang.pdf
  file_size: 3982516
  relation: main_file
file_date_updated: 2020-07-14T12:47:49Z
has_accepted_license: '1'
intvolume: '        15'
isi: 1
issue: '11'
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '754411'
  name: ISTplus - Postdoctoral Fellowships
publication: PLoS Computational Biology
publication_identifier:
  issn:
  - 1553-7358
publication_status: published
publisher: Public Library of Science
quality_controlled: '1'
scopus_import: '1'
status: public
title: Non-equilibrium critical dynamics of bursts in θ and δ rhythms as fundamental
  characteristic of sleep and wake micro-architecture
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2019'
...