--- res: bibo_abstract: - Loss of functional cardiomyocytes is a major determinant of heart failure after myocardial infarction. Previous high throughput screening studies have identified a few microRNAs (miRNAs) that can induce cardiomyocyte proliferation and stimulate cardiac regeneration in mice. Here, we show that all of the most effective of these miRNAs activate nuclear localization of the master transcriptional cofactor Yes-associated protein (YAP) and induce expression of YAP-responsive genes. In particular, miR-199a-3p directly targets two mRNAs coding for proteins impinging on the Hippo pathway, the upstream YAP inhibitory kinase TAOK1, and the E3 ubiquitin ligase β-TrCP, which leads to YAP degradation. Several of the pro-proliferative miRNAs (including miR-199a-3p) also inhibit filamentous actin depolymerization by targeting Cofilin2, a process that by itself activates YAP nuclear translocation. Thus, activation of YAP and modulation of the actin cytoskeleton are major components of the pro-proliferative action of miR-199a-3p and other miRNAs that induce cardiomyocyte proliferation.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Consuelo foaf_name: Torrini, Consuelo foaf_surname: Torrini - foaf_Person: foaf_givenName: Ryan J foaf_name: Cubero, Ryan J foaf_surname: Cubero foaf_workInfoHomepage: http://www.librecat.org/personId=850B2E12-9CD4-11E9-837F-E719E6697425 orcid: 0000-0003-0002-1867 - foaf_Person: foaf_givenName: Ellen foaf_name: Dirkx, Ellen foaf_surname: Dirkx - foaf_Person: foaf_givenName: Luca foaf_name: Braga, Luca foaf_surname: Braga - foaf_Person: foaf_givenName: Hashim foaf_name: Ali, Hashim foaf_surname: Ali - foaf_Person: foaf_givenName: Giulia foaf_name: Prosdocimo, Giulia foaf_surname: Prosdocimo - foaf_Person: foaf_givenName: Maria Ines foaf_name: Gutierrez, Maria Ines foaf_surname: Gutierrez - foaf_Person: foaf_givenName: Chiara foaf_name: Collesi, Chiara foaf_surname: Collesi - foaf_Person: foaf_givenName: Danilo foaf_name: Licastro, Danilo foaf_surname: Licastro - foaf_Person: foaf_givenName: Lorena foaf_name: Zentilin, Lorena foaf_surname: Zentilin - foaf_Person: foaf_givenName: Miguel foaf_name: Mano, Miguel foaf_surname: Mano - foaf_Person: foaf_givenName: Serena foaf_name: Zacchigna, Serena foaf_surname: Zacchigna - foaf_Person: foaf_givenName: Michele foaf_name: Vendruscolo, Michele foaf_surname: Vendruscolo - foaf_Person: foaf_givenName: Matteo foaf_name: Marsili, Matteo foaf_surname: Marsili - foaf_Person: foaf_givenName: Areejit foaf_name: Samal, Areejit foaf_surname: Samal - foaf_Person: foaf_givenName: Mauro foaf_name: Giacca, Mauro foaf_surname: Giacca bibo_doi: 10.1016/j.celrep.2019.05.005 bibo_issue: '9' bibo_volume: 27 dct_date: 2019^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/2211-1247 dct_language: eng dct_publisher: Elsevier@ dct_subject: - cardiomyocyte - cell cycle - Cofilin2 - cytoskeleton - Hippo - microRNA - regeneration - YAP dct_title: Common regulatory pathways mediate activity of microRNAs inducing cardiomyocyte proliferation@ fabio_hasPubmedId: '31141697' ...