--- res: bibo_abstract: - To determine the dynamics of allelic-specific expression during mouse development, we analyzed RNA-seq data from 23 F1 tissues from different developmental stages, including 19 female tissues allowing X chromosome inactivation (XCI) escapers to also be detected. We demonstrate that allelic expression arising from genetic or epigenetic differences is highly tissue-specific. We find that tissue-specific strain-biased gene expression may be regulated by tissue-specific enhancers or by post-transcriptional differences in stability between the alleles. We also find that escape from X-inactivation is tissue-specific, with leg muscle showing an unexpectedly high rate of XCI escapers. By surveying a range of tissues during development, and performing extensive validation, we are able to provide a high confidence list of mouse imprinted genes including 18 novel genes. This shows that cluster size varies dynamically during development and can be substantially larger than previously thought, with the Igf2r cluster extending over 10 Mb in placenta.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Daniel foaf_name: Andergassen, Daniel foaf_surname: Andergassen - foaf_Person: foaf_givenName: Christoph foaf_name: Dotter, Christoph foaf_surname: Dotter foaf_workInfoHomepage: http://www.librecat.org/personId=4C66542E-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Dyniel foaf_name: Wenzel, Dyniel foaf_surname: Wenzel - foaf_Person: foaf_givenName: Verena foaf_name: Sigl, Verena foaf_surname: Sigl - foaf_Person: foaf_givenName: Philipp foaf_name: Bammer, Philipp foaf_surname: Bammer - foaf_Person: foaf_givenName: Markus foaf_name: Muckenhuber, Markus foaf_surname: Muckenhuber - foaf_Person: foaf_givenName: Daniela foaf_name: Mayer, Daniela foaf_surname: Mayer - foaf_Person: foaf_givenName: Tomasz foaf_name: Kulinski, Tomasz foaf_surname: Kulinski - foaf_Person: foaf_givenName: Hans foaf_name: Theussl, Hans foaf_surname: Theussl - foaf_Person: foaf_givenName: Josef foaf_name: Penninger, Josef foaf_surname: Penninger - foaf_Person: foaf_givenName: Christoph foaf_name: Bock, Christoph foaf_surname: Bock - foaf_Person: foaf_givenName: Denise foaf_name: Barlow, Denise foaf_surname: Barlow - foaf_Person: foaf_givenName: Florian foaf_name: Pauler, Florian foaf_surname: Pauler foaf_workInfoHomepage: http://www.librecat.org/personId=48EA0138-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Quanah foaf_name: Hudson, Quanah foaf_surname: Hudson bibo_doi: 10.7554/eLife.25125 bibo_volume: 6 dct_date: 2017^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/2050084X dct_language: eng dct_publisher: eLife Sciences Publications@ dct_title: Mapping the mouse Allelome reveals tissue specific regulation of allelic expression@ ...