---
res:
  bibo_abstract:
  - Background HIV-1 infection and drug abuse are frequently co-morbid and their association
    greatly increases the severity of HIV-1-induced neuropathology. While nucleus
    accumbens (NAcc) function is severely perturbed by drugs of abuse, little is known
    about how HIV-1 infection affects NAcc. Methods We used calcium and voltage imaging
    to investigate the effect of HIV-1 trans-activator of transcription (Tat) on rat
    NAcc. Based on previous neuronal studies, we hypothesized that Tat modulates intracellular
    Ca2+ homeostasis of NAcc neurons. Results We provide evidence that Tat triggers
    a Ca2+ signaling cascade in NAcc medium spiny neurons (MSN) expressing D1-like
    dopamine receptors leading to neuronal depolarization. Firstly, Tat induced inositol
    1,4,5-trisphsophate (IP3) receptor-mediated Ca2+ release from endoplasmic reticulum,
    followed by Ca2+ and Na+ influx via transient receptor potential canonical channels.
    The influx of cations depolarizes the membrane promoting additional Ca2+ entry
    through voltage-gated P/Q-type Ca2+ channels and opening of tetrodotoxin-sensitive
    Na+ channels. By activating this mechanism, Tat elicits a feed-forward depolarization
    increasing the excitability of D1-phosphatidylinositol-linked NAcc MSN. We previously
    found that cocaine targets NAcc neurons directly (independent of the inhibition
    of dopamine transporter) only when IP3-generating mechanisms are concomitantly
    initiated. When tested here, cocaine produced a dose-dependent potentiation of
    the effect of Tat on cytosolic Ca2+. Conclusion We describe for the first time
    a HIV-1 Tat-triggered Ca2+ signaling in MSN of NAcc involving TRPC and depolarization
    and a potentiation of the effect of Tat by cocaine, which may be relevant for
    the reward axis in cocaine-abusing HIV-1-positive patients.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Gabriela
      foaf_name: Brailoiu, Gabriela
      foaf_surname: Brailoiu
  - foaf_Person:
      foaf_givenName: Elena
      foaf_name: Deliu, Elena
      foaf_surname: Deliu
      foaf_workInfoHomepage: http://www.librecat.org/personId=37A40D7E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-7370-5293
  - foaf_Person:
      foaf_givenName: Jeffrey
      foaf_name: Barr, Jeffrey
      foaf_surname: Barr
  - foaf_Person:
      foaf_givenName: Linda
      foaf_name: Console Bram, Linda
      foaf_surname: Console Bram
  - foaf_Person:
      foaf_givenName: Alexandra
      foaf_name: Ciuciu, Alexandra
      foaf_surname: Ciuciu
  - foaf_Person:
      foaf_givenName: Mary
      foaf_name: Abood, Mary
      foaf_surname: Abood
  - foaf_Person:
      foaf_givenName: Ellen
      foaf_name: Unterwald, Ellen
      foaf_surname: Unterwald
  - foaf_Person:
      foaf_givenName: Eugen
      foaf_name: Brǎiloiu, Eugen
      foaf_surname: Brǎiloiu
  bibo_doi: 10.1016/j.drugalcdep.2017.04.015
  bibo_volume: 178
  dct_date: 2017^xs_gYear
  dct_identifier:
  - UT:000409152300002
  dct_isPartOf:
  - http://id.crossref.org/issn/0376-8716
  dct_language: eng
  dct_publisher: Elsevier@
  dct_title: HIV Tat excites D1 receptor-like expressing neurons from rat nucleus
    accumbens@
  fabio_hasPubmedId: '28623807'
...