---
res:
  bibo_abstract:
  - "The expression of a gene is characterised by its transcription factors and the
    function processing them. If the transcription factors are not affected by gene
    products, the regulating function is often represented as a combinational logic
    circuit, where the outputs (product) are determined by current input values (transcription
    factors) only, and are hence independent on their relative arrival times. However,
    the simultaneous arrival of transcription factors (TFs) in genetic circuits is
    a strong assumption, given that the processes of transcription and translation
    of a gene into a protein introduce intrinsic time delays and that there is no
    global synchronisation among the arrival times of different molecular species
    at molecular targets.\r\n\r\nIn this paper, we construct an experimentally implementable
    genetic circuit with two inputs and a single output, such that, in presence of
    small delays in input arrival, the circuit exhibits qualitatively distinct observable
    phenotypes. In particular, these phenotypes are long lived transients: they all
    converge to a single value, but so slowly, that they seem stable for an extended
    time period, longer than typical experiment duration. We used rule-based language
    to prototype our circuit, and we implemented a search for finding the parameter
    combinations raising the phenotypes of interest.\r\n\r\nThe behaviour of our prototype
    circuit has wide implications. First, it suggests that GRNs can exploit event
    timing to create phenotypes. Second, it opens the possibility that GRNs are using
    event timing to react to stimuli and memorise events, without explicit feedback
    in regulation. From the modelling perspective, our prototype circuit demonstrates
    the critical importance of analysing the transient dynamics at the promoter binding
    sites of the DNA, before applying rapid equilibrium assumptions.@eng"
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Calin C
      foaf_name: Guet, Calin C
      foaf_surname: Guet
      foaf_workInfoHomepage: http://www.librecat.org/personId=47F8433E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6220-2052
  - foaf_Person:
      foaf_givenName: Thomas A
      foaf_name: Henzinger, Thomas A
      foaf_surname: Henzinger
      foaf_workInfoHomepage: http://www.librecat.org/personId=40876CD8-F248-11E8-B48F-1D18A9856A87
    orcid: 0000−0002−2985−7724
  - foaf_Person:
      foaf_givenName: Claudia
      foaf_name: Igler, Claudia
      foaf_surname: Igler
      foaf_workInfoHomepage: http://www.librecat.org/personId=46613666-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7777-546X
  - foaf_Person:
      foaf_givenName: Tatjana
      foaf_name: Petrov, Tatjana
      foaf_surname: Petrov
      foaf_workInfoHomepage: http://www.librecat.org/personId=3D5811FC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-9041-0905
  - foaf_Person:
      foaf_givenName: Ali
      foaf_name: Sezgin, Ali
      foaf_surname: Sezgin
      foaf_workInfoHomepage: http://www.librecat.org/personId=4C7638DA-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.1007/978-3-030-31304-3_9
  bibo_volume: 11773
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000557875100009
  dct_isPartOf:
  - http://id.crossref.org/issn/0302-9743
  - http://id.crossref.org/issn/1611-3349
  - http://id.crossref.org/issn/9783030313036
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Transient memory in gene regulation@
...