{"date_published":"2020-01-01T00:00:00Z","pmid":1,"issue":"1","acknowledgement":" Dipartimento DiSS, Università degli Studi di Milano, Grant/Award Number: Linea 2; Fondazione Cariplo, Grant/Award Number: 2015-0783; German Federal Ministry of Education and Research (BMBF), Grant/Award Number: CHROMATIN-Net; Medical Faculty of the University of Lübeck, Grant/Award Number: J09-2017; Nickel & Co S.p.A.; Università degli Studi di Milano, Grant/Award Numbers: Molecular & Translational Medicine PhD Scholarship, Translational Medicine PhD Scholarship","quality_controlled":"1","type":"journal_article","date_created":"2019-12-04T16:10:59Z","author":[{"last_name":"Avagliano","full_name":"Avagliano, Laura","first_name":"Laura"},{"last_name":"Parenti","full_name":"Parenti, Ilaria","id":"D93538B0-5B71-11E9-AC62-02EBE5697425","first_name":"Ilaria"},{"full_name":"Grazioli, Paolo","first_name":"Paolo","last_name":"Grazioli"},{"last_name":"Di Fede","first_name":"Elisabetta","full_name":"Di Fede, Elisabetta"},{"last_name":"Parodi","first_name":"Chiara","full_name":"Parodi, Chiara"},{"full_name":"Mariani, Milena","first_name":"Milena","last_name":"Mariani"},{"last_name":"Kaiser","first_name":"Frank J.","full_name":"Kaiser, Frank J."},{"full_name":"Selicorni, Angelo","first_name":"Angelo","last_name":"Selicorni"},{"first_name":"Cristina","full_name":"Gervasini, Cristina","last_name":"Gervasini"},{"full_name":"Massa, Valentina","first_name":"Valentina","last_name":"Massa"}],"publication_identifier":{"issn":["0009-9163"],"eissn":["1399-0004"]},"date_updated":"2023-08-17T14:06:20Z","day":"01","scopus_import":"1","article_processing_charge":"No","intvolume":"        97","external_id":{"isi":["000562561800001"],"pmid":["31721174"]},"month":"01","article_type":"review","isi":1,"title":"Chromatinopathies: A focus on Cornelia de Lange syndrome","year":"2020","abstract":[{"lang":"eng","text":"In recent years, many genes have been associated with chromatinopathies classified as “Cornelia de Lange Syndrome‐like.” It is known that the phenotype of these patients becomes less recognizable, overlapping to features characteristic of other syndromes caused by genetic variants affecting different regulators of chromatin structure and function. Therefore, Cornelia de Lange syndrome diagnosis might be arduous due to the seldom discordance between unexpected molecular diagnosis and clinical evaluation. Here, we review the molecular features of Cornelia de Lange syndrome, supporting the hypothesis that “CdLS‐like syndromes” are part of a larger “rare disease family” sharing multiple clinical features and common disrupted molecular pathways."}],"_id":"7149","status":"public","publication":"Clinical Genetics","department":[{"_id":"GaNo"}],"oa_version":"None","doi":"10.1111/cge.13674","language":[{"iso":"eng"}],"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Wiley","page":"3-11","publication_status":"published","citation":{"chicago":"Avagliano, Laura, Ilaria Parenti, Paolo Grazioli, Elisabetta Di Fede, Chiara Parodi, Milena Mariani, Frank J. Kaiser, Angelo Selicorni, Cristina Gervasini, and Valentina Massa. “Chromatinopathies: A Focus on Cornelia de Lange Syndrome.” <i>Clinical Genetics</i>. Wiley, 2020. <a href=\"https://doi.org/10.1111/cge.13674\">https://doi.org/10.1111/cge.13674</a>.","short":"L. Avagliano, I. Parenti, P. Grazioli, E. Di Fede, C. Parodi, M. Mariani, F.J. Kaiser, A. Selicorni, C. Gervasini, V. Massa, Clinical Genetics 97 (2020) 3–11.","mla":"Avagliano, Laura, et al. “Chromatinopathies: A Focus on Cornelia de Lange Syndrome.” <i>Clinical Genetics</i>, vol. 97, no. 1, Wiley, 2020, pp. 3–11, doi:<a href=\"https://doi.org/10.1111/cge.13674\">10.1111/cge.13674</a>.","ieee":"L. Avagliano <i>et al.</i>, “Chromatinopathies: A focus on Cornelia de Lange syndrome,” <i>Clinical Genetics</i>, vol. 97, no. 1. Wiley, pp. 3–11, 2020.","ista":"Avagliano L, Parenti I, Grazioli P, Di Fede E, Parodi C, Mariani M, Kaiser FJ, Selicorni A, Gervasini C, Massa V. 2020. Chromatinopathies: A focus on Cornelia de Lange syndrome. Clinical Genetics. 97(1), 3–11.","apa":"Avagliano, L., Parenti, I., Grazioli, P., Di Fede, E., Parodi, C., Mariani, M., … Massa, V. (2020). Chromatinopathies: A focus on Cornelia de Lange syndrome. <i>Clinical Genetics</i>. Wiley. <a href=\"https://doi.org/10.1111/cge.13674\">https://doi.org/10.1111/cge.13674</a>","ama":"Avagliano L, Parenti I, Grazioli P, et al. Chromatinopathies: A focus on Cornelia de Lange syndrome. <i>Clinical Genetics</i>. 2020;97(1):3-11. doi:<a href=\"https://doi.org/10.1111/cge.13674\">10.1111/cge.13674</a>"},"volume":97}