---
_id: '7166'
abstract:
- lang: eng
  text: In the living cell, we encounter a large variety of motile processes such
    as organelle transport and cytoskeleton remodeling. These processes are driven
    by motor proteins that generate force by transducing chemical free energy into
    mechanical work. In many cases, the molecular motors work in teams to collectively
    generate larger forces. Recent optical trapping experiments on small teams of
    cytoskeletal motors indicated that the collectively generated force increases
    with the size of the motor team but that this increase depends on the motor type
    and on whether the motors are studied in vitro or in vivo. Here, we use the theory
    of stochastic processes to describe the motion of N motors in a stationary optical
    trap and to compute the N-dependence of the collectively generated forces. We
    consider six distinct motor types, two kinesins, two dyneins, and two myosins.
    We show that the force increases always linearly with N but with a prefactor that
    depends on the performance of the single motor. Surprisingly, this prefactor increases
    for weaker motors with a lower stall force. This counter-intuitive behavior reflects
    the increased probability with which stronger motors detach from the filament
    during strain generation. Our theoretical results are in quantitative agreement
    with experimental data on small teams of kinesin-1 motors.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Mehmet C
  full_name: Ucar, Mehmet C
  id: 50B2A802-6007-11E9-A42B-EB23E6697425
  last_name: Ucar
  orcid: 0000-0003-0506-4217
- first_name: Reinhard
  full_name: Lipowsky, Reinhard
  last_name: Lipowsky
citation:
  ama: Ucar MC, Lipowsky R. Collective force generation by molecular motors is determined
    by strain-induced unbinding. <i>Nano Letters</i>. 2020;20(1):669-676. doi:<a href="https://doi.org/10.1021/acs.nanolett.9b04445">10.1021/acs.nanolett.9b04445</a>
  apa: Ucar, M. C., &#38; Lipowsky, R. (2020). Collective force generation by molecular
    motors is determined by strain-induced unbinding. <i>Nano Letters</i>. American
    Chemical Society. <a href="https://doi.org/10.1021/acs.nanolett.9b04445">https://doi.org/10.1021/acs.nanolett.9b04445</a>
  chicago: Ucar, Mehmet C, and Reinhard Lipowsky. “Collective Force Generation by
    Molecular Motors Is Determined by Strain-Induced Unbinding.” <i>Nano Letters</i>.
    American Chemical Society, 2020. <a href="https://doi.org/10.1021/acs.nanolett.9b04445">https://doi.org/10.1021/acs.nanolett.9b04445</a>.
  ieee: M. C. Ucar and R. Lipowsky, “Collective force generation by molecular motors
    is determined by strain-induced unbinding,” <i>Nano Letters</i>, vol. 20, no.
    1. American Chemical Society, pp. 669–676, 2020.
  ista: Ucar MC, Lipowsky R. 2020. Collective force generation by molecular motors
    is determined by strain-induced unbinding. Nano Letters. 20(1), 669–676.
  mla: Ucar, Mehmet C., and Reinhard Lipowsky. “Collective Force Generation by Molecular
    Motors Is Determined by Strain-Induced Unbinding.” <i>Nano Letters</i>, vol. 20,
    no. 1, American Chemical Society, 2020, pp. 669–76, doi:<a href="https://doi.org/10.1021/acs.nanolett.9b04445">10.1021/acs.nanolett.9b04445</a>.
  short: M.C. Ucar, R. Lipowsky, Nano Letters 20 (2020) 669–676.
corr_author: '1'
date_created: 2019-12-10T15:36:05Z
date_published: 2020-01-08T00:00:00Z
date_updated: 2024-10-09T20:59:07Z
day: '08'
department:
- _id: EdHa
doi: 10.1021/acs.nanolett.9b04445
external_id:
  isi:
  - '000507151600087'
  pmid:
  - '31797672'
intvolume: '        20'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://doi.org/10.1021/acs.nanolett.9b04445
month: '01'
oa: 1
oa_version: Published Version
page: 669-676
pmid: 1
publication: Nano Letters
publication_identifier:
  eissn:
  - 1530-6992
  issn:
  - 1530-6984
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
related_material:
  record:
  - id: '9726'
    relation: research_data
    status: public
  - id: '9885'
    relation: research_data
    status: public
scopus_import: '1'
status: public
title: Collective force generation by molecular motors is determined by strain-induced
  unbinding
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2020'
...