---
res:
  bibo_abstract:
  - During infection pathogens secrete small molecules, termed effectors, to manipulate
    and control the interaction with their specific hosts. Both the pathogen and the
    plant are under high selective pressure to rapidly adapt and co-evolve in what
    is usually referred to as molecular arms race. Components of the host’s immune
    system form a network that processes information about molecules with a foreign
    origin and damage-associated signals, integrating them with developmental and
    abiotic cues to adapt the plant’s responses. Both in the case of nucleotide-binding
    leucine-rich repeat receptors and leucine-rich repeat receptor kinases interaction
    networks have been extensively characterized. However, little is known on whether
    pathogenic effectors form complexes to overcome plant immunity and promote disease.
    Ustilago maydis, a biotrophic fungal pathogen that infects maize plants, produces
    effectors that target hubs in the immune network of the host cell. Here we assess
    the capability of U. maydis effector candidates to interact with each other, which
    may play a crucial role during the infection process. Using a systematic yeast-two-hybrid
    approach and based on a preliminary pooled screen, we selected 63 putative effectors
    for one-on-one matings with a library of nearly 300 effector candidates. We found
    that 126 of these effector candidates interacted either with themselves or other
    predicted effectors. Although the functional relevance of the observed interactions
    remains elusive, we propose that the observed abundance in complex formation between
    effectors adds an additional level of complexity to effector research and should
    be taken into consideration when studying effector evolution and function. Based
    on this fundamental finding, we suggest various scenarios which could evolutionarily
    drive the formation and stabilization of an effector interactome.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: André
      foaf_name: Alcântara, André
      foaf_surname: Alcântara
  - foaf_Person:
      foaf_givenName: Jason
      foaf_name: Bosch, Jason
      foaf_surname: Bosch
  - foaf_Person:
      foaf_givenName: Fahimeh
      foaf_name: Nazari, Fahimeh
      foaf_surname: Nazari
  - foaf_Person:
      foaf_givenName: Gesa
      foaf_name: Hoffmann, Gesa
      foaf_surname: Hoffmann
  - foaf_Person:
      foaf_givenName: Michelle C
      foaf_name: Gallei, Michelle C
      foaf_surname: Gallei
      foaf_workInfoHomepage: http://www.librecat.org/personId=35A03822-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1286-7368
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Uhse, Simon
      foaf_surname: Uhse
  - foaf_Person:
      foaf_givenName: Martin A.
      foaf_name: Darino, Martin A.
      foaf_surname: Darino
  - foaf_Person:
      foaf_givenName: Toluwase
      foaf_name: Olukayode, Toluwase
      foaf_surname: Olukayode
  - foaf_Person:
      foaf_givenName: Daniel
      foaf_name: Reumann, Daniel
      foaf_surname: Reumann
  - foaf_Person:
      foaf_givenName: Laura
      foaf_name: Baggaley, Laura
      foaf_surname: Baggaley
  - foaf_Person:
      foaf_givenName: Armin
      foaf_name: Djamei, Armin
      foaf_surname: Djamei
  bibo_doi: 10.3389/fpls.2019.01437
  bibo_issue: '11'
  bibo_volume: 10
  dct_date: 2019^xs_gYear
  dct_identifier:
  - UT:000499821700001
  dct_isPartOf:
  - http://id.crossref.org/issn/1664-462X
  dct_language: eng
  dct_publisher: Frontiers@
  dct_title: Systematic Y2H screening reveals extensive effector-complex formation@
  fabio_hasPubmedId: '31803201'
...