---
_id: '7202'
abstract:
- lang: eng
  text: The cerebral cortex contains multiple areas with distinctive cytoarchitectonical
    patterns, but the cellular mechanisms underlying the emergence of this diversity
    remain unclear. Here, we have investigated the neuronal output of individual progenitor
    cells in the developing mouse neocortex using a combination of methods that together
    circumvent the biases and limitations of individual approaches. Our experimental
    results indicate that progenitor cells generate pyramidal cell lineages with a
    wide range of sizes and laminar configurations. Mathematical modelling indicates
    that these outcomes are compatible with a stochastic model of cortical neurogenesis
    in which progenitor cells undergo a series of probabilistic decisions that lead
    to the specification of very heterogeneous progenies. Our findings support a mechanism
    for cortical neurogenesis whose flexibility would make it capable to generate
    the diverse cytoarchitectures that characterize distinct neocortical areas.
article_number: e51381
article_processing_charge: No
article_type: original
author:
- first_name: Alfredo
  full_name: Llorca, Alfredo
  last_name: Llorca
- first_name: Gabriele
  full_name: Ciceri, Gabriele
  last_name: Ciceri
- first_name: Robert J
  full_name: Beattie, Robert J
  id: 2E26DF60-F248-11E8-B48F-1D18A9856A87
  last_name: Beattie
  orcid: 0000-0002-8483-8753
- first_name: Fong Kuan
  full_name: Wong, Fong Kuan
  last_name: Wong
- first_name: Giovanni
  full_name: Diana, Giovanni
  last_name: Diana
- first_name: Eleni
  full_name: Serafeimidou-Pouliou, Eleni
  last_name: Serafeimidou-Pouliou
- first_name: Marian
  full_name: Fernández-Otero, Marian
  last_name: Fernández-Otero
- first_name: Carmen
  full_name: Streicher, Carmen
  id: 36BCB99C-F248-11E8-B48F-1D18A9856A87
  last_name: Streicher
- first_name: Sebastian J.
  full_name: Arnold, Sebastian J.
  last_name: Arnold
- first_name: Martin
  full_name: Meyer, Martin
  last_name: Meyer
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Miguel
  full_name: Maravall, Miguel
  last_name: Maravall
- first_name: Oscar
  full_name: Marín, Oscar
  last_name: Marín
citation:
  ama: Llorca A, Ciceri G, Beattie RJ, et al. A stochastic framework of neurogenesis
    underlies the assembly of neocortical cytoarchitecture. <i>eLife</i>. 2019;8.
    doi:<a href="https://doi.org/10.7554/eLife.51381">10.7554/eLife.51381</a>
  apa: Llorca, A., Ciceri, G., Beattie, R. J., Wong, F. K., Diana, G., Serafeimidou-Pouliou,
    E., … Marín, O. (2019). A stochastic framework of neurogenesis underlies the assembly
    of neocortical cytoarchitecture. <i>ELife</i>. eLife Sciences Publications. <a
    href="https://doi.org/10.7554/eLife.51381">https://doi.org/10.7554/eLife.51381</a>
  chicago: Llorca, Alfredo, Gabriele Ciceri, Robert J Beattie, Fong Kuan Wong, Giovanni
    Diana, Eleni Serafeimidou-Pouliou, Marian Fernández-Otero, et al. “A Stochastic
    Framework of Neurogenesis Underlies the Assembly of Neocortical Cytoarchitecture.”
    <i>ELife</i>. eLife Sciences Publications, 2019. <a href="https://doi.org/10.7554/eLife.51381">https://doi.org/10.7554/eLife.51381</a>.
  ieee: A. Llorca <i>et al.</i>, “A stochastic framework of neurogenesis underlies
    the assembly of neocortical cytoarchitecture,” <i>eLife</i>, vol. 8. eLife Sciences
    Publications, 2019.
  ista: Llorca A, Ciceri G, Beattie RJ, Wong FK, Diana G, Serafeimidou-Pouliou E,
    Fernández-Otero M, Streicher C, Arnold SJ, Meyer M, Hippenmeyer S, Maravall M,
    Marín O. 2019. A stochastic framework of neurogenesis underlies the assembly of
    neocortical cytoarchitecture. eLife. 8, e51381.
  mla: Llorca, Alfredo, et al. “A Stochastic Framework of Neurogenesis Underlies the
    Assembly of Neocortical Cytoarchitecture.” <i>ELife</i>, vol. 8, e51381, eLife
    Sciences Publications, 2019, doi:<a href="https://doi.org/10.7554/eLife.51381">10.7554/eLife.51381</a>.
  short: A. Llorca, G. Ciceri, R.J. Beattie, F.K. Wong, G. Diana, E. Serafeimidou-Pouliou,
    M. Fernández-Otero, C. Streicher, S.J. Arnold, M. Meyer, S. Hippenmeyer, M. Maravall,
    O. Marín, ELife 8 (2019).
date_created: 2019-12-22T23:00:42Z
date_published: 2019-11-18T00:00:00Z
date_updated: 2026-04-03T09:46:33Z
day: '18'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.7554/eLife.51381
ec_funded: 1
external_id:
  isi:
  - '000508156800001'
  pmid:
  - '31736464'
file:
- access_level: open_access
  checksum: b460ecc33e1a68265e7adea775021f3a
  content_type: application/pdf
  creator: dernst
  date_created: 2020-02-18T15:19:26Z
  date_updated: 2020-07-14T12:47:53Z
  file_id: '7503'
  file_name: 2019_eLife_Llorca.pdf
  file_size: 2960543
  relation: main_file
file_date_updated: 2020-07-14T12:47:53Z
has_accepted_license: '1'
intvolume: '         8'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '11'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
- _id: 264E56E2-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: M02416
  name: Molecular Mechanisms Regulating Gliogenesis in the Neocortex
publication: eLife
publication_identifier:
  eissn:
  - 2050-084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: A stochastic framework of neurogenesis underlies the assembly of neocortical
  cytoarchitecture
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 8
year: '2019'
...