--- res: bibo_abstract: - The rate of biological evolution depends on the fixation probability and on the fixation time of new mutants. Intensive research has focused on identifying population structures that augment the fixation probability of advantageous mutants. But these amplifiers of natural selection typically increase fixation time. Here we study population structures that achieve a tradeoff between fixation probability and time. First, we show that no amplifiers can have an asymptotically lower absorption time than the well-mixed population. Then we design population structures that substantially augment the fixation probability with just a minor increase in fixation time. Finally, we show that those structures enable higher effective rate of evolution than the well-mixed population provided that the rate of generating advantageous mutants is relatively low. Our work sheds light on how population structure affects the rate of evolution. Moreover, our structures could be useful for lab-based, medical, or industrial applications of evolutionary optimization.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Josef foaf_name: Tkadlec, Josef foaf_surname: Tkadlec foaf_workInfoHomepage: http://www.librecat.org/personId=3F24CCC8-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-1097-9684 - foaf_Person: foaf_givenName: Andreas foaf_name: Pavlogiannis, Andreas foaf_surname: Pavlogiannis foaf_workInfoHomepage: http://www.librecat.org/personId=49704004-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8943-0722 - foaf_Person: foaf_givenName: Krishnendu foaf_name: Chatterjee, Krishnendu foaf_surname: Chatterjee foaf_workInfoHomepage: http://www.librecat.org/personId=2E5DCA20-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-4561-241X - foaf_Person: foaf_givenName: Martin A. foaf_name: Nowak, Martin A. foaf_surname: Nowak bibo_doi: 10.1038/s42003-019-0373-y bibo_volume: 2 dct_date: 2019^xs_gYear dct_identifier: - UT:000465425700006 dct_isPartOf: - http://id.crossref.org/issn/2399-3642 dct_language: eng dct_publisher: Springer Nature@ dct_title: Population structure determines the tradeoff between fixation probability and fixation time@ fabio_hasPubmedId: '31044163' ...