---
res:
  bibo_abstract:
  - Cytoskeletal filaments such as microtubules (MTs) and filamentous actin (F-actin)
    dynamically support cell structure and functions. In central presynaptic terminals,
    F-actin is expressed along the release edge and reportedly plays diverse functional
    roles, but whether axonal MTs extend deep into terminals and play any physiological
    role remains controversial. At the calyx of Held in rats of either sex, confocal
    and high-resolution microscopy revealed that MTs enter deep into presynaptic terminal
    swellings and partially colocalize with a subset of synaptic vesicles (SVs). Electrophysiological
    analysis demonstrated that depolymerization of MTs specifically prolonged the
    slow-recovery time component of EPSCs from short-term depression induced by a
    train of high-frequency stimulation, whereas depolymerization of F-actin specifically
    prolonged the fast-recovery component. In simultaneous presynaptic and postsynaptic
    action potential recordings, depolymerization of MTs or F-actin significantly
    impaired the fidelity of high-frequency neurotransmission. We conclude that MTs
    and F-actin differentially contribute to slow and fast SV replenishment, thereby
    maintaining high-frequency neurotransmission.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Lashmi
      foaf_name: Piriya Ananda Babu, Lashmi
      foaf_surname: Piriya Ananda Babu
  - foaf_Person:
      foaf_givenName: Han Ying
      foaf_name: Wang, Han Ying
      foaf_surname: Wang
  - foaf_Person:
      foaf_givenName: Kohgaku
      foaf_name: Eguchi, Kohgaku
      foaf_surname: Eguchi
      foaf_workInfoHomepage: http://www.librecat.org/personId=2B7846DC-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-6170-2546
  - foaf_Person:
      foaf_givenName: Laurent
      foaf_name: Guillaud, Laurent
      foaf_surname: Guillaud
  - foaf_Person:
      foaf_givenName: Tomoyuki
      foaf_name: Takahashi, Tomoyuki
      foaf_surname: Takahashi
  bibo_doi: 10.1523/JNEUROSCI.1571-19.2019
  bibo_issue: '1'
  bibo_volume: 40
  dct_date: 2020^xs_gYear
  dct_identifier:
  - UT:000505167600013
  dct_isPartOf:
  - http://id.crossref.org/issn/0270-6474
  - http://id.crossref.org/issn/1529-2401
  dct_language: eng
  dct_publisher: Society for Neuroscience@
  dct_title: Microtubule and actin differentially regulate synaptic vesicle cycling
    to maintain high-frequency neurotransmission@
  fabio_hasPubmedId: '31767677'
...