---
res:
  bibo_abstract:
  - The ability to sense environmental temperature and to coordinate growth and development
    accordingly, is critical to the reproductive success of plants. Flowering time
    is regulated at the level of gene expression by a complex network of factors that
    integrate environmental and developmental cues. One of the main players, involved
    in modulating flowering time in response to changes in ambient temperature is
    FLOWERING LOCUS M (FLM). FLM transcripts can undergo extensive alternative splicing
    producing multiple variants, of which FLM-β and FLM-δ are the most representative.
    While FLM-β codes for the flowering repressor FLM protein, translation of FLM-δ
    has the opposite effect on flowering. Here we show that the cyclin-dependent kinase
    G2 (CDKG2), together with its cognate cyclin, CYCLYN L1 (CYCL1) affects the alternative
    splicing of FLM, balancing the levels of FLM-β and FLM-δ across the ambient temperature
    range. In the absence of the CDKG2/CYCL1 complex, FLM-β expression is reduced
    while FLM-δ is increased in a temperature dependent manner and these changes are
    associated with an early flowering phenotype in the cdkg2 mutant lines. In addition,
    we found that transcript variants retaining the full FLM intron 1 are sequestered
    in the cell nucleus. Strikingly, FLM intron 1 splicing is also regulated by CDKG2/CYCL1.
    Our results provide evidence that temperature and CDKs regulate the alternative
    splicing of FLM, contributing to flowering time definition.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Candida
      foaf_name: Nibau, Candida
      foaf_surname: Nibau
  - foaf_Person:
      foaf_givenName: Marçal
      foaf_name: Gallemi, Marçal
      foaf_surname: Gallemi
      foaf_workInfoHomepage: http://www.librecat.org/personId=460C6802-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4675-6893
  - foaf_Person:
      foaf_givenName: Despoina
      foaf_name: Dadarou, Despoina
      foaf_surname: Dadarou
  - foaf_Person:
      foaf_givenName: John H.
      foaf_name: Doonan, John H.
      foaf_surname: Doonan
  - foaf_Person:
      foaf_givenName: Nicola
      foaf_name: Cavallari, Nicola
      foaf_surname: Cavallari
      foaf_workInfoHomepage: http://www.librecat.org/personId=457160E6-F248-11E8-B48F-1D18A9856A87
  bibo_doi: 10.3389/fpls.2019.01680
  bibo_volume: 10
  dct_date: 2020^xs_gYear
  dct_identifier:
  - UT:000511376000001
  dct_isPartOf:
  - http://id.crossref.org/issn/1664-462X
  dct_language: eng
  dct_publisher: Frontiers Media@
  dct_title: Thermo-sensitive alternative splicing of FLOWERING LOCUS M is modulated
    by cyclin-dependent kinase G2@
  fabio_hasPubmedId: '32038671'
...