--- res: bibo_abstract: - Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Shutang foaf_name: Tan, Shutang foaf_surname: Tan foaf_workInfoHomepage: http://www.librecat.org/personId=2DE75584-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-0471-8285 - foaf_Person: foaf_givenName: Melinda F foaf_name: Abas, Melinda F foaf_surname: Abas foaf_workInfoHomepage: http://www.librecat.org/personId=3CFB3B1C-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Inge foaf_name: Verstraeten, Inge foaf_surname: Verstraeten foaf_workInfoHomepage: http://www.librecat.org/personId=362BF7FE-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-7241-2328 - foaf_Person: foaf_givenName: Matous foaf_name: Glanc, Matous foaf_surname: Glanc foaf_workInfoHomepage: http://www.librecat.org/personId=1AE1EA24-02D0-11E9-9BAA-DAF4881429F2 orcid: 0000-0003-0619-7783 - foaf_Person: foaf_givenName: Gergely foaf_name: Molnar, Gergely foaf_surname: Molnar foaf_workInfoHomepage: http://www.librecat.org/personId=34F1AF46-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Jakub foaf_name: Hajny, Jakub foaf_surname: Hajny foaf_workInfoHomepage: http://www.librecat.org/personId=4800CC20-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-2140-7195 - foaf_Person: foaf_givenName: Pavel foaf_name: Lasák, Pavel foaf_surname: Lasák - foaf_Person: foaf_givenName: Ivan foaf_name: Petřík, Ivan foaf_surname: Petřík - foaf_Person: foaf_givenName: Eugenia foaf_name: Russinova, Eugenia foaf_surname: Russinova - foaf_Person: foaf_givenName: Jan foaf_name: Petrášek, Jan foaf_surname: Petrášek - foaf_Person: foaf_givenName: Ondřej foaf_name: Novák, Ondřej foaf_surname: Novák - foaf_Person: foaf_givenName: Jiří foaf_name: Pospíšil, Jiří foaf_surname: Pospíšil - foaf_Person: foaf_givenName: Jiří foaf_name: Friml, Jiří foaf_surname: Friml foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8302-7596 bibo_doi: 10.1016/j.cub.2019.11.058 bibo_issue: '3' bibo_volume: 30 dct_date: 2020^xs_gYear dct_identifier: - UT:000511287900018 dct_isPartOf: - http://id.crossref.org/issn/09609822 dct_language: eng dct_publisher: Cell Press@ dct_title: Salicylic acid targets protein phosphatase 2A to attenuate growth in plants@ fabio_hasPubmedId: '31956021' ...