article published yes Shutang Tan author 2DE75584-F248-11E8-B48F-1D18A9856A870000-0002-0471-8285 Melinda F Abas author 3CFB3B1C-F248-11E8-B48F-1D18A9856A87 Inge Verstraeten author 362BF7FE-F248-11E8-B48F-1D18A9856A870000-0001-7241-2328 Matous Glanc author 1AE1EA24-02D0-11E9-9BAA-DAF4881429F20000-0003-0619-7783 Gergely Molnar author 34F1AF46-F248-11E8-B48F-1D18A9856A87 Jakub Hajny author 4800CC20-F248-11E8-B48F-1D18A9856A870000-0003-2140-7195 Pavel Lasák author Ivan Petřík author Eugenia Russinova author Jan Petrášek author Ondřej Novák author Jiří Pospíšil author Jiří Friml author 4159519E-F248-11E8-B48F-1D18A9856A870000-0002-8302-7596 JiFr department EvBe department Tracing Evolution of Auxin Transport and Polarity in Plants project International IST Postdoc Fellowship Programme project Molecular Mechanism underlying Salicylic Acid Regulation of Endocytic Trafficking in Arabidopsis project Plants, like other multicellular organisms, survive through a delicate balance between growth and defense against pathogens. Salicylic acid (SA) is a major defense signal in plants, and the perception mechanism as well as downstream signaling activating the immune response are known. Here, we identify a parallel SA signaling that mediates growth attenuation. SA directly binds to A subunits of protein phosphatase 2A (PP2A), inhibiting activity of this complex. Among PP2A targets, the PIN2 auxin transporter is hyperphosphorylated in response to SA, leading to changed activity of this important growth regulator. Accordingly, auxin transport and auxin-mediated root development, including growth, gravitropic response, and lateral root organogenesis, are inhibited. This study reveals how SA, besides activating immunity, concomitantly attenuates growth through crosstalk with the auxin distribution network. Further analysis of this dual role of SA and characterization of additional SA-regulated PP2A targets will provide further insights into mechanisms maintaining a balance between growth and defense. https://research-explorer.ista.ac.at/download/7427/8555/2020_CurrentBiology_Tan.pdf application/pdfno https://creativecommons.org/licenses/by/4.0/ Cell Press2020 eng 09609822 31956021 00051128790001810.1016/j.cub.2019.11.058 303381-395.e8 https://research-explorer.ista.ac.at/record/8822 Tan, S., Abas, M. F., Verstraeten, I., Glanc, M., Molnar, G., Hajny, J., … Friml, J. (2020). Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. <i>Current Biology</i>. Cell Press. <a href="https://doi.org/10.1016/j.cub.2019.11.058">https://doi.org/10.1016/j.cub.2019.11.058</a> Tan S, Abas MF, Verstraeten I, et al. Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. <i>Current Biology</i>. 2020;30(3):381-395.e8. doi:<a href="https://doi.org/10.1016/j.cub.2019.11.058">10.1016/j.cub.2019.11.058</a> S. Tan, M.F. Abas, I. Verstraeten, M. Glanc, G. Molnar, J. Hajny, P. Lasák, I. Petřík, E. Russinova, J. Petrášek, O. Novák, J. Pospíšil, J. Friml, Current Biology 30 (2020) 381–395.e8. S. Tan <i>et al.</i>, “Salicylic acid targets protein phosphatase 2A to attenuate growth in plants,” <i>Current Biology</i>, vol. 30, no. 3. Cell Press, p. 381–395.e8, 2020. Tan, Shutang, Melinda F Abas, Inge Verstraeten, Matous Glanc, Gergely Molnar, Jakub Hajny, Pavel Lasák, et al. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.” <i>Current Biology</i>. Cell Press, 2020. <a href="https://doi.org/10.1016/j.cub.2019.11.058">https://doi.org/10.1016/j.cub.2019.11.058</a>. Tan, Shutang, et al. “Salicylic Acid Targets Protein Phosphatase 2A to Attenuate Growth in Plants.” <i>Current Biology</i>, vol. 30, no. 3, Cell Press, 2020, p. 381–395.e8, doi:<a href="https://doi.org/10.1016/j.cub.2019.11.058">10.1016/j.cub.2019.11.058</a>. Tan S, Abas MF, Verstraeten I, Glanc M, Molnar G, Hajny J, Lasák P, Petřík I, Russinova E, Petrášek J, Novák O, Pospíšil J, Friml J. 2020. Salicylic acid targets protein phosphatase 2A to attenuate growth in plants. Current Biology. 30(3), 381–395.e8. 74272020-02-02T23:01:00Z2026-08-08T22:30:52Z