{"related_material":{"record":[{"relation":"dissertation_contains","id":"324","status":"public"}]},"ec_funded":1,"day":"21","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png"},"date_updated":"2023-09-27T12:26:04Z","intvolume":"        21","abstract":[{"text":"Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous transmitter release and facilitation at synapses. However, Syt7 is strongly expressed in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output synapses of these neurons produce only minimal asynchronous release and show depression rather than facilitation. To resolve this apparent contradiction, we examined the effects of genetic elimination of Syt7 on synaptic transmission at the GABAergic basket cell (BC)-Purkinje cell (PC) synapse in cerebellum. Our results indicate that at the BC-PC synapse, Syt7 contributes to asynchronous release, pool replenishment, and facilitation. In combination, these three effects ensure efficient transmitter release during high-frequency activity and guarantee frequency independence of inhibition. Our results identify a distinct function of Syt7: ensuring the efficiency of high-frequency inhibitory synaptic transmission","lang":"eng"}],"status":"public","has_accepted_license":"1","external_id":{"isi":["000416216700007"]},"isi":1,"pubrep_id":"874","volume":21,"project":[{"grant_number":"P24909-B24","call_identifier":"FWF","name":"Mechanisms of transmitter release at GABAergic synapses","_id":"25C26B1E-B435-11E9-9278-68D0E5697425"},{"name":"Biophysics and circuit function of a giant cortical glumatergic synapse","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"692692"}],"page":"2082 - 2089","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","department":[{"_id":"PeJo"}],"language":[{"iso":"eng"}],"file_date_updated":"2020-07-14T12:47:59Z","publist_id":"6907","author":[{"last_name":"Chen","id":"3DFD581A-F248-11E8-B48F-1D18A9856A87","full_name":"Chen, Chong","first_name":"Chong"},{"full_name":"Satterfield, Rachel","first_name":"Rachel","last_name":"Satterfield"},{"last_name":"Young","first_name":"Samuel","full_name":"Young, Samuel"},{"first_name":"Peter M","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","last_name":"Jonas"}],"file":[{"checksum":"a6afa3764909bf6edafa07982d8e1cee","creator":"system","file_id":"4737","access_level":"open_access","relation":"main_file","date_updated":"2020-07-14T12:47:59Z","content_type":"application/pdf","file_size":2759195,"date_created":"2018-12-12T10:09:14Z","file_name":"IST-2017-874-v1+1_PIIS2211124717316029.pdf"}],"year":"2017","ddc":["570","571"],"date_published":"2017-11-21T00:00:00Z","article_processing_charge":"No","publication":"Cell Reports","date_created":"2018-12-11T11:48:18Z","oa_version":"Published Version","citation":{"apa":"Chen, C., Satterfield, R., Young, S., &#38; Jonas, P. M. (2017). Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central GABAergic synapses. <i>Cell Reports</i>. Cell Press. <a href=\"https://doi.org/10.1016/j.celrep.2017.10.122\">https://doi.org/10.1016/j.celrep.2017.10.122</a>","short":"C. Chen, R. Satterfield, S. Young, P.M. Jonas, Cell Reports 21 (2017) 2082–2089.","chicago":"Chen, Chong, Rachel Satterfield, Samuel Young, and Peter M Jonas. “Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses.” <i>Cell Reports</i>. Cell Press, 2017. <a href=\"https://doi.org/10.1016/j.celrep.2017.10.122\">https://doi.org/10.1016/j.celrep.2017.10.122</a>.","ieee":"C. Chen, R. Satterfield, S. Young, and P. M. Jonas, “Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central GABAergic synapses,” <i>Cell Reports</i>, vol. 21, no. 8. Cell Press, pp. 2082–2089, 2017.","mla":"Chen, Chong, et al. “Triple Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission at Central GABAergic Synapses.” <i>Cell Reports</i>, vol. 21, no. 8, Cell Press, 2017, pp. 2082–89, doi:<a href=\"https://doi.org/10.1016/j.celrep.2017.10.122\">10.1016/j.celrep.2017.10.122</a>.","ista":"Chen C, Satterfield R, Young S, Jonas PM. 2017. Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central GABAergic synapses. Cell Reports. 21(8), 2082–2089.","ama":"Chen C, Satterfield R, Young S, Jonas PM. Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central GABAergic synapses. <i>Cell Reports</i>. 2017;21(8):2082-2089. doi:<a href=\"https://doi.org/10.1016/j.celrep.2017.10.122\">10.1016/j.celrep.2017.10.122</a>"},"type":"journal_article","publication_identifier":{"issn":["22111247"]},"doi":"10.1016/j.celrep.2017.10.122","acknowledged_ssus":[{"_id":"PreCl"}],"_id":"749","title":"Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central GABAergic synapses","issue":"8","month":"11","publication_status":"published","oa":1,"scopus_import":"1","publisher":"Cell Press"}