---
_id: '749'
abstract:
- lang: eng
  text: 'Synaptotagmin 7 (Syt7) is thought to be a Ca2+ sensor that mediates asynchronous
    transmitter release and facilitation at synapses. However, Syt7 is strongly expressed
    in fast-spiking, parvalbumin-expressing GABAergic interneurons, and the output
    synapses of these neurons produce only minimal asynchronous release and show depression
    rather than facilitation. To resolve this apparent contradiction, we examined
    the effects of genetic elimination of Syt7 on synaptic transmission at the GABAergic
    basket cell (BC)-Purkinje cell (PC) synapse in cerebellum. Our results indicate
    that at the BC-PC synapse, Syt7 contributes to asynchronous release, pool replenishment,
    and facilitation. In combination, these three effects ensure efficient transmitter
    release during high-frequency activity and guarantee frequency independence of
    inhibition. Our results identify a distinct function of Syt7: ensuring the efficiency
    of high-frequency inhibitory synaptic transmission'
acknowledged_ssus:
- _id: PreCl
article_processing_charge: No
author:
- first_name: Chong
  full_name: Chen, Chong
  id: 3DFD581A-F248-11E8-B48F-1D18A9856A87
  last_name: Chen
- first_name: Rachel
  full_name: Satterfield, Rachel
  last_name: Satterfield
- first_name: Samuel
  full_name: Young, Samuel
  last_name: Young
- first_name: Peter M
  full_name: Jonas, Peter M
  id: 353C1B58-F248-11E8-B48F-1D18A9856A87
  last_name: Jonas
  orcid: 0000-0001-5001-4804
citation:
  ama: Chen C, Satterfield R, Young S, Jonas PM. Triple function of Synaptotagmin
    7 ensures efficiency of high-frequency transmission at central GABAergic synapses.
    <i>Cell Reports</i>. 2017;21(8):2082-2089. doi:<a href="https://doi.org/10.1016/j.celrep.2017.10.122">10.1016/j.celrep.2017.10.122</a>
  apa: Chen, C., Satterfield, R., Young, S., &#38; Jonas, P. M. (2017). Triple function
    of Synaptotagmin 7 ensures efficiency of high-frequency transmission at central
    GABAergic synapses. <i>Cell Reports</i>. Cell Press. <a href="https://doi.org/10.1016/j.celrep.2017.10.122">https://doi.org/10.1016/j.celrep.2017.10.122</a>
  chicago: Chen, Chong, Rachel Satterfield, Samuel Young, and Peter M Jonas. “Triple
    Function of Synaptotagmin 7 Ensures Efficiency of High-Frequency Transmission
    at Central GABAergic Synapses.” <i>Cell Reports</i>. Cell Press, 2017. <a href="https://doi.org/10.1016/j.celrep.2017.10.122">https://doi.org/10.1016/j.celrep.2017.10.122</a>.
  ieee: C. Chen, R. Satterfield, S. Young, and P. M. Jonas, “Triple function of Synaptotagmin
    7 ensures efficiency of high-frequency transmission at central GABAergic synapses,”
    <i>Cell Reports</i>, vol. 21, no. 8. Cell Press, pp. 2082–2089, 2017.
  ista: Chen C, Satterfield R, Young S, Jonas PM. 2017. Triple function of Synaptotagmin
    7 ensures efficiency of high-frequency transmission at central GABAergic synapses.
    Cell Reports. 21(8), 2082–2089.
  mla: Chen, Chong, et al. “Triple Function of Synaptotagmin 7 Ensures Efficiency
    of High-Frequency Transmission at Central GABAergic Synapses.” <i>Cell Reports</i>,
    vol. 21, no. 8, Cell Press, 2017, pp. 2082–89, doi:<a href="https://doi.org/10.1016/j.celrep.2017.10.122">10.1016/j.celrep.2017.10.122</a>.
  short: C. Chen, R. Satterfield, S. Young, P.M. Jonas, Cell Reports 21 (2017) 2082–2089.
corr_author: '1'
date_created: 2018-12-11T11:48:18Z
date_published: 2017-11-21T00:00:00Z
date_updated: 2026-04-08T14:09:28Z
day: '21'
ddc:
- '570'
- '571'
department:
- _id: PeJo
doi: 10.1016/j.celrep.2017.10.122
ec_funded: 1
external_id:
  isi:
  - '000416216700007'
file:
- access_level: open_access
  checksum: a6afa3764909bf6edafa07982d8e1cee
  content_type: application/pdf
  creator: system
  date_created: 2018-12-12T10:09:14Z
  date_updated: 2020-07-14T12:47:59Z
  file_id: '4737'
  file_name: IST-2017-874-v1+1_PIIS2211124717316029.pdf
  file_size: 2759195
  relation: main_file
file_date_updated: 2020-07-14T12:47:59Z
fulldoi: https://doi.org/10.1016/j.celrep.2017.10.122
has_accepted_license: '1'
intvolume: '        21'
isi: 1
issue: '8'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 2082 - 2089
project:
- _id: 25C26B1E-B435-11E9-9278-68D0E5697425
  call_identifier: FWF
  grant_number: P24909-B24
  name: Mechanisms of transmitter release at GABAergic synapses
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '692692'
  name: Biophysics and circuit function of a giant cortical glutamatergic synapse
publication: Cell Reports
publication_identifier:
  issn:
  - 2211-1247
publication_status: published
publisher: Cell Press
publist_id: '6907'
pubrep_id: '874'
quality_controlled: '1'
related_material:
  record:
  - id: '324'
    relation: dissertation_contains
    status: public
scopus_import: '1'
status: public
title: Triple function of Synaptotagmin 7 ensures efficiency of high-frequency transmission
  at central GABAergic synapses
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 21
year: '2017'
...