---
res:
  bibo_abstract:
  - The extent to which behavior is shaped by experience varies between individuals.
    Genetic differences contribute to this variation, but the neural mechanisms are
    not understood. Here, we dissect natural variation in the behavioral flexibility
    of two Caenorhabditis elegans wild strains. In one strain, a memory of exposure
    to 21% O2 suppresses CO2-evoked locomotory arousal; in the other, CO2 evokes arousal
    regardless of previous O2 experience. We map that variation to a polymorphic dendritic
    scaffold protein, ARCP-1, expressed in sensory neurons. ARCP-1 binds the Ca2+-dependent
    phosphodiesterase PDE-1 and co-localizes PDE-1 with molecular sensors for CO2
    at dendritic ends. Reducing ARCP-1 or PDE-1 activity promotes CO2 escape by altering
    neuropeptide expression in the BAG CO2 sensors. Variation in ARCP-1 alters behavioral
    plasticity in multiple paradigms. Our findings are reminiscent of genetic accommodation,
    an evolutionary process by which phenotypic flexibility in response to environmental
    variation is reset by genetic change.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Isabel
      foaf_name: Beets, Isabel
      foaf_surname: Beets
  - foaf_Person:
      foaf_givenName: Gaotian
      foaf_name: Zhang, Gaotian
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Lorenz A.
      foaf_name: Fenk, Lorenz A.
      foaf_surname: Fenk
  - foaf_Person:
      foaf_givenName: Changchun
      foaf_name: Chen, Changchun
      foaf_surname: Chen
  - foaf_Person:
      foaf_givenName: Geoffrey M.
      foaf_name: Nelson, Geoffrey M.
      foaf_surname: Nelson
  - foaf_Person:
      foaf_givenName: Marie-Anne
      foaf_name: Félix, Marie-Anne
      foaf_surname: Félix
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: de Bono, Mario
      foaf_surname: de Bono
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8347-0443
  bibo_doi: 10.1016/j.neuron.2019.10.001
  bibo_issue: '1'
  bibo_volume: 105
  dct_date: 2020^xs_gYear
  dct_identifier:
  - UT:000507341300012
  dct_isPartOf:
  - http://id.crossref.org/issn/0896-6273
  dct_language: eng
  dct_publisher: Cell Press@
  dct_title: Natural variation in a dendritic scaffold protein remodels experience-dependent
    plasticity by altering neuropeptide expression@
  fabio_hasPubmedId: '31757604'
...