---
res:
  bibo_abstract:
  - Although the aggregation of the amyloid-β peptide (Aβ) into amyloid fibrils is
    a well-established hallmark of Alzheimer’s disease, the complex mechanisms linking
    this process to neurodegeneration are still incompletely understood. The nematode
    worm C. elegans is a valuable model organism through which to study these mechanisms
    because of its simple nervous system and its relatively short lifespan. Standard
    Aβ-based C. elegans models of Alzheimer’s disease are designed to study the toxic
    effects of the overexpression of Aβ in the muscle or nervous systems. However,
    the wide variety of effects associated with the tissue-level overexpression of
    Aβ makes it difficult to single out and study specific cellular mechanisms related
    to the onset of Alzheimer’s disease. Here, to better understand how to investigate
    the early events affecting neuronal signalling, we created a C. elegans model
    expressing Aβ42, the 42-residue form of Aβ, from a single-copy gene insertion
    in just one pair of glutamatergic sensory neurons, the BAG neurons. In behavioural
    assays, we found that the Aβ42-expressing animals displayed a subtle modulation
    of the response to CO2, compared to controls. Ca2+ imaging revealed that the BAG
    neurons in young Aβ42-expressing nematodes were activated more strongly than in
    control animals, and that neuronal activation remained intact until old age. Taken
    together, our results suggest that Aβ42-expression in this very subtle model of
    AD is sufficient to modulate the behavioural response but not strong enough to
    generate significant neurotoxicity, suggesting that slightly more aggressive perturbations
    will enable effectively studies of the links between the modulation of a physiological
    response and its associated neurotoxicity.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Tessa
      foaf_name: Sinnige, Tessa
      foaf_surname: Sinnige
  - foaf_Person:
      foaf_givenName: Prashanth
      foaf_name: Ciryam, Prashanth
      foaf_surname: Ciryam
  - foaf_Person:
      foaf_givenName: Samuel
      foaf_name: Casford, Samuel
      foaf_surname: Casford
  - foaf_Person:
      foaf_givenName: Christopher M.
      foaf_name: Dobson, Christopher M.
      foaf_surname: Dobson
  - foaf_Person:
      foaf_givenName: Mario
      foaf_name: de Bono, Mario
      foaf_surname: de Bono
      foaf_workInfoHomepage: http://www.librecat.org/personId=4E3FF80E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-8347-0443
  - foaf_Person:
      foaf_givenName: Michele
      foaf_name: Vendruscolo, Michele
      foaf_surname: Vendruscolo
  bibo_doi: 10.1371/journal.pone.0217746
  bibo_issue: '5'
  bibo_volume: 14
  dct_date: 2019^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/1932-6203
  dct_language: eng
  dct_publisher: Public Library of Science@
  dct_title: Expression of the amyloid-β peptide in a single pair of C. elegans sensory
    neurons modulates the associated behavioural response@
...