---
res:
  bibo_abstract:
  - The eukaryotic endomembrane system is controlled by small GTPases of the Rab family,
    which are activated at defined times and locations in a switch-like manner. While
    this switch is well understood for an individual protein, how regulatory networks
    produce intracellular activity patterns is currently not known. Here, we combine
    in vitro reconstitution experiments with computational modeling to study a minimal
    Rab5 activation network. We find that the molecular interactions in this system
    give rise to a positive feedback and bistable collective switching of Rab5. Furthermore,
    we find that switching near the critical point is intrinsically stochastic and
    provide evidence that controlling the inactive population of Rab5 on the membrane
    can shape the network response. Notably, we demonstrate that collective switching
    can spread on the membrane surface as a traveling wave of Rab5 activation. Together,
    our findings reveal how biochemical signaling networks control vesicle trafficking
    pathways and how their nonequilibrium properties define the spatiotemporal organization
    of the cell.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Urban
      foaf_name: Bezeljak, Urban
      foaf_surname: Bezeljak
      foaf_workInfoHomepage: http://www.librecat.org/personId=2A58201A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1365-5631
  - foaf_Person:
      foaf_givenName: Hrushikesh
      foaf_name: Loya, Hrushikesh
      foaf_surname: Loya
  - foaf_Person:
      foaf_givenName: Beata M
      foaf_name: Kaczmarek, Beata M
      foaf_surname: Kaczmarek
      foaf_workInfoHomepage: http://www.librecat.org/personId=36FA4AFA-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Timothy E.
      foaf_name: Saunders, Timothy E.
      foaf_surname: Saunders
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Loose, Martin
      foaf_surname: Loose
      foaf_workInfoHomepage: http://www.librecat.org/personId=462D4284-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-7309-9724
  bibo_doi: 10.1073/pnas.1921027117
  bibo_issue: '12'
  bibo_volume: 117
  dct_date: 2020^xs_gYear
  dct_identifier:
  - UT:000521821800040
  dct_isPartOf:
  - http://id.crossref.org/issn/0027-8424
  - http://id.crossref.org/issn/1091-6490
  dct_language: eng
  dct_publisher: National Academy of Sciences@
  dct_title: Stochastic activation and bistability in a Rab GTPase regulatory network@
  fabio_hasPubmedId: '32161136'
...