--- res: bibo_abstract: - Longitudinal axon fascicles within the Drosophila embryonic CNS provide connections between body segments and are required for coordinated neural signaling along the anterior-posterior axis. We show here that establishment of select CNS longitudinal tracts and formation of precise mechanosensory afferent innervation to the same CNS region are coordinately regulated by the secreted semaphorins Sema-2a and Sema-2b. Both Sema-2a and Sema-2b utilize the same neuronal receptor, plexin B (PlexB), but serve distinct guidance functions. Localized Sema-2b attraction promotes the initial assembly of a subset of CNS longitudinal projections and subsequent targeting of chordotonal sensory afferent axons to these same longitudinal connectives, whereas broader Sema-2a repulsion serves to prevent aberrant innervation. In the absence of Sema-2b or PlexB, chordotonal afferent connectivity within the CNS is severely disrupted, resulting in specific larval behavioral deficits. These results reveal that distinct semaphorin-mediated guidance functions converge at PlexB and are critical for functional neural circuit assembly.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Zhuhao foaf_name: Wu, Zhuhao foaf_surname: Wu - foaf_Person: foaf_givenName: Lora Beatrice Jaeger foaf_name: Sweeney, Lora Beatrice Jaeger foaf_surname: Sweeney foaf_workInfoHomepage: http://www.librecat.org/personId=56BE8254-C4F0-11E9-8E45-0B23E6697425 orcid: 0000-0001-9242-5601 - foaf_Person: foaf_givenName: Joseph C. foaf_name: Ayoob, Joseph C. foaf_surname: Ayoob - foaf_Person: foaf_givenName: Kayam foaf_name: Chak, Kayam foaf_surname: Chak - foaf_Person: foaf_givenName: Benjamin J. foaf_name: Andreone, Benjamin J. foaf_surname: Andreone - foaf_Person: foaf_givenName: Tomoko foaf_name: Ohyama, Tomoko foaf_surname: Ohyama - foaf_Person: foaf_givenName: Rex foaf_name: Kerr, Rex foaf_surname: Kerr - foaf_Person: foaf_givenName: Liqun foaf_name: Luo, Liqun foaf_surname: Luo - foaf_Person: foaf_givenName: Marta foaf_name: Zlatic, Marta foaf_surname: Zlatic - foaf_Person: foaf_givenName: Alex L. foaf_name: Kolodkin, Alex L. foaf_surname: Kolodkin bibo_doi: 10.1016/j.neuron.2011.02.050 bibo_issue: '2' bibo_volume: 70 dct_date: 2011^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0896-6273 dct_language: eng dct_publisher: Elsevier@ dct_title: A combinatorial semaphorin code instructs the initial steps of sensory circuit assembly in the Drosophila CNS@ ...