--- res: bibo_abstract: - Axon-axon interactions have been implicated in neural circuit assembly, but the underlying mechanisms are poorly understood. Here, we show that in the Drosophila antennal lobe, early-arriving axons of olfactory receptor neurons (ORNs) from the antenna are required for the proper targeting of late-arriving ORN axons from the maxillary palp (MP). Semaphorin-1a is required for targeting of all MP but only half of the antennal ORN classes examined. Sema-1a acts nonautonomously to control ORN axon-axon interactions, in contrast to its cell-autonomous function in olfactory projection neurons. Phenotypic and genetic interaction analyses implicate PlexinA as the Sema-1a receptor in ORN targeting. Sema-1a on antennal ORN axons is required for correct targeting of MP axons within the antennal lobe, while interactions amongst MP axons facilitate their entry into the antennal lobe. We propose that Sema-1a/PlexinA-mediated repulsion provides a mechanism by which early-arriving ORN axons constrain the target choices of late-arriving axons.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Lora Beatrice Jaeger foaf_name: Sweeney, Lora Beatrice Jaeger foaf_surname: Sweeney foaf_workInfoHomepage: http://www.librecat.org/personId=56BE8254-C4F0-11E9-8E45-0B23E6697425 orcid: 0000-0001-9242-5601 - foaf_Person: foaf_givenName: Africa foaf_name: Couto, Africa foaf_surname: Couto - foaf_Person: foaf_givenName: Ya-Hui foaf_name: Chou, Ya-Hui foaf_surname: Chou - foaf_Person: foaf_givenName: Daniela foaf_name: Berdnik, Daniela foaf_surname: Berdnik - foaf_Person: foaf_givenName: Barry J. foaf_name: Dickson, Barry J. foaf_surname: Dickson - foaf_Person: foaf_givenName: Liqun foaf_name: Luo, Liqun foaf_surname: Luo - foaf_Person: foaf_givenName: Takaki foaf_name: Komiyama, Takaki foaf_surname: Komiyama bibo_doi: 10.1016/j.neuron.2006.12.022 bibo_issue: '2' bibo_volume: 53 dct_date: 2007^xs_gYear dct_isPartOf: - http://id.crossref.org/issn/0896-6273 dct_language: eng dct_publisher: Elsevier@ dct_title: Temporal target restriction of olfactory receptor neurons by semaphorin-1a/plexinA-mediated axon-axon interactions@ ...