{"year":"2018","day":"26","quality_controlled":"1","article_processing_charge":"No","date_published":"2018-11-26T00:00:00Z","intvolume":"         2","publication":"Nature Human Behaviour","date_updated":"2021-01-12T08:15:03Z","date_created":"2020-04-30T10:42:12Z","status":"public","abstract":[{"text":"Preference for mates with similar phenotypes; that is, assortative mating, is widely observed in humans1,2,3,4,5 and has evolutionary consequences6,7,8. Under Fisher's classical theory6, assortative mating is predicted to induce a signature in the genome at trait-associated loci that can be detected and quantified. Here, we develop and apply a method to quantify assortative mating on a specific trait by estimating the correlation (θ) between genetic predictors of the trait from single nucleotide polymorphisms on odd- versus even-numbered chromosomes. We show by theory and simulation that the effect of assortative mating can be quantified in the presence of population stratification. We applied this approach to 32 complex traits and diseases using single nucleotide polymorphism data from ~400,000 unrelated individuals of European ancestry. We found significant evidence of assortative mating for height (θ = 3.2%) and educational attainment (θ = 2.7%), both of which were consistent with theoretical predictions. Overall, our results imply that assortative mating involves multiple traits and affects the genomic architecture of loci that are associated with these traits, and that the consequence of mate choice can be detected from a random sample of genomes.","lang":"eng"}],"page":"948-954","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"extern":"1","author":[{"last_name":"Yengo","first_name":"Loic","full_name":"Yengo, Loic"},{"last_name":"Robinson","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","orcid":"0000-0001-8982-8813","first_name":"Matthew Richard","full_name":"Robinson, Matthew Richard"},{"last_name":"Keller","first_name":"Matthew C.","full_name":"Keller, Matthew C."},{"last_name":"Kemper","full_name":"Kemper, Kathryn E.","first_name":"Kathryn E."},{"first_name":"Yuanhao","full_name":"Yang, Yuanhao","last_name":"Yang"},{"last_name":"Trzaskowski","full_name":"Trzaskowski, Maciej","first_name":"Maciej"},{"last_name":"Gratten","first_name":"Jacob","full_name":"Gratten, Jacob"},{"last_name":"Turley","first_name":"Patrick","full_name":"Turley, Patrick"},{"last_name":"Cesarini","first_name":"David","full_name":"Cesarini, David"},{"first_name":"Daniel J.","full_name":"Benjamin, Daniel J.","last_name":"Benjamin"},{"last_name":"Wray","first_name":"Naomi R.","full_name":"Wray, Naomi R."},{"first_name":"Michael E.","full_name":"Goddard, Michael E.","last_name":"Goddard"},{"last_name":"Yang","first_name":"Jian","full_name":"Yang, Jian"},{"first_name":"Peter M.","full_name":"Visscher, Peter M.","last_name":"Visscher"}],"volume":2,"publication_status":"published","publisher":"Springer Nature","oa_version":"None","article_type":"original","citation":{"apa":"Yengo, L., Robinson, M. R., Keller, M. C., Kemper, K. E., Yang, Y., Trzaskowski, M., … Visscher, P. M. (2018). Imprint of assortative mating on the human genome. <i>Nature Human Behaviour</i>. Springer Nature. <a href=\"https://doi.org/10.1038/s41562-018-0476-3\">https://doi.org/10.1038/s41562-018-0476-3</a>","short":"L. Yengo, M.R. Robinson, M.C. Keller, K.E. Kemper, Y. Yang, M. Trzaskowski, J. Gratten, P. Turley, D. Cesarini, D.J. Benjamin, N.R. Wray, M.E. Goddard, J. Yang, P.M. Visscher, Nature Human Behaviour 2 (2018) 948–954.","ieee":"L. Yengo <i>et al.</i>, “Imprint of assortative mating on the human genome,” <i>Nature Human Behaviour</i>, vol. 2, no. 12. Springer Nature, pp. 948–954, 2018.","chicago":"Yengo, Loic, Matthew Richard Robinson, Matthew C. Keller, Kathryn E. Kemper, Yuanhao Yang, Maciej Trzaskowski, Jacob Gratten, et al. “Imprint of Assortative Mating on the Human Genome.” <i>Nature Human Behaviour</i>. Springer Nature, 2018. <a href=\"https://doi.org/10.1038/s41562-018-0476-3\">https://doi.org/10.1038/s41562-018-0476-3</a>.","mla":"Yengo, Loic, et al. “Imprint of Assortative Mating on the Human Genome.” <i>Nature Human Behaviour</i>, vol. 2, no. 12, Springer Nature, 2018, pp. 948–54, doi:<a href=\"https://doi.org/10.1038/s41562-018-0476-3\">10.1038/s41562-018-0476-3</a>.","ama":"Yengo L, Robinson MR, Keller MC, et al. Imprint of assortative mating on the human genome. <i>Nature Human Behaviour</i>. 2018;2(12):948-954. doi:<a href=\"https://doi.org/10.1038/s41562-018-0476-3\">10.1038/s41562-018-0476-3</a>","ista":"Yengo L, Robinson MR, Keller MC, Kemper KE, Yang Y, Trzaskowski M, Gratten J, Turley P, Cesarini D, Benjamin DJ, Wray NR, Goddard ME, Yang J, Visscher PM. 2018. Imprint of assortative mating on the human genome. Nature Human Behaviour. 2(12), 948–954."},"type":"journal_article","_id":"7715","publication_identifier":{"issn":["2397-3374"]},"doi":"10.1038/s41562-018-0476-3","month":"11","title":"Imprint of assortative mating on the human genome","issue":"12"}