{"article_processing_charge":"No","extern":"1","related_material":{"link":[{"url":"https://doi.org/10.1073/pnas.1718598115","relation":"other"}]},"issue":"32","language":[{"iso":"eng"}],"publisher":"Proceedings of the National Academy of Sciences","abstract":[{"lang":"eng","text":"Quantifying the effects of inbreeding is critical to characterizing the genetic architecture of complex traits. This study highlights through theory and simulations the strengths and shortcomings of three SNP-based inbreeding measures commonly used to estimate inbreeding depression (ID). We demonstrate that heterogeneity in linkage disequilibrium (LD) between causal variants and SNPs biases ID estimates, and we develop an approach to correct this bias using LD and minor allele frequency stratified inference (LDMS). We quantified ID in 25 traits measured in ∼140,000 participants of the UK Biobank, using LDMS, and confirmed previously published ID for 4 traits. We find unique evidence of ID for handgrip strength, waist/hip ratio, and visual and auditory acuity (ID between −2.3 and −5.2 phenotypic SDs for complete inbreeding; P<0.001). Our results illustrate that a careful choice of the measure of inbreeding combined with LDMS stratification improves both detection and quantification of ID using SNP data."}],"intvolume":"       114","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_type":"original","doi":"10.1073/pnas.1621096114","publication_status":"published","citation":{"mla":"Yengo, Loic, et al. “Detection and Quantification of Inbreeding Depression for Complex Traits from SNP Data.” <i>Proceedings of the National Academy of Sciences</i>, vol. 114, no. 32, Proceedings of the National Academy of Sciences, 2017, pp. 8602–07, doi:<a href=\"https://doi.org/10.1073/pnas.1621096114\">10.1073/pnas.1621096114</a>.","ista":"Yengo L, Zhu Z, Wray NR, Weir BS, Yang J, Robinson MR, Visscher PM. 2017. Detection and quantification of inbreeding depression for complex traits from SNP data. Proceedings of the National Academy of Sciences. 114(32), 8602–8607.","apa":"Yengo, L., Zhu, Z., Wray, N. R., Weir, B. S., Yang, J., Robinson, M. R., &#38; Visscher, P. M. (2017). Detection and quantification of inbreeding depression for complex traits from SNP data. <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1621096114\">https://doi.org/10.1073/pnas.1621096114</a>","short":"L. Yengo, Z. Zhu, N.R. Wray, B.S. Weir, J. Yang, M.R. Robinson, P.M. Visscher, Proceedings of the National Academy of Sciences 114 (2017) 8602–8607.","ieee":"L. Yengo <i>et al.</i>, “Detection and quantification of inbreeding depression for complex traits from SNP data,” <i>Proceedings of the National Academy of Sciences</i>, vol. 114, no. 32. Proceedings of the National Academy of Sciences, pp. 8602–8607, 2017.","ama":"Yengo L, Zhu Z, Wray NR, et al. Detection and quantification of inbreeding depression for complex traits from SNP data. <i>Proceedings of the National Academy of Sciences</i>. 2017;114(32):8602-8607. doi:<a href=\"https://doi.org/10.1073/pnas.1621096114\">10.1073/pnas.1621096114</a>","chicago":"Yengo, Loic, Zhihong Zhu, Naomi R. Wray, Bruce S. Weir, Jian Yang, Matthew Richard Robinson, and Peter M. Visscher. “Detection and Quantification of Inbreeding Depression for Complex Traits from SNP Data.” <i>Proceedings of the National Academy of Sciences</i>. Proceedings of the National Academy of Sciences, 2017. <a href=\"https://doi.org/10.1073/pnas.1621096114\">https://doi.org/10.1073/pnas.1621096114</a>."},"oa_version":"None","type":"journal_article","day":"08","year":"2017","status":"public","author":[{"first_name":"Loic","last_name":"Yengo","full_name":"Yengo, Loic"},{"full_name":"Zhu, Zhihong","last_name":"Zhu","first_name":"Zhihong"},{"first_name":"Naomi R.","last_name":"Wray","full_name":"Wray, Naomi R."},{"first_name":"Bruce S.","last_name":"Weir","full_name":"Weir, Bruce S."},{"full_name":"Yang, Jian","last_name":"Yang","first_name":"Jian"},{"orcid":"0000-0001-8982-8813","first_name":"Matthew Richard","id":"E5D42276-F5DA-11E9-8E24-6303E6697425","last_name":"Robinson","full_name":"Robinson, Matthew Richard"},{"first_name":"Peter M.","full_name":"Visscher, Peter M.","last_name":"Visscher"}],"publication_identifier":{"issn":["0027-8424","1091-6490"]},"date_published":"2017-08-08T00:00:00Z","_id":"7729","quality_controlled":"1","title":"Detection and quantification of inbreeding depression for complex traits from SNP data","date_updated":"2021-01-12T08:15:09Z","month":"08","page":"8602-8607","volume":114,"date_created":"2020-04-30T10:47:19Z","publication":"Proceedings of the National Academy of Sciences"}