---
_id: '7789'
abstract:
- lang: eng
text: During embryonic and postnatal development, organs and tissues grow steadily
to achieve their final size at the end of puberty. However, little is known about
the cellular dynamics that mediate postnatal growth. By combining in vivo clonal
lineage tracing, proliferation kinetics, single-cell transcriptomics, andin vitro
micro-pattern experiments, we resolved the cellular dynamics taking place during
postnatal skin epidermis expansion. Our data revealed that harmonious growth is
engineered by a single population of developmental progenitors presenting a fixed
fate imbalance of self-renewing divisions with an ever-decreasing proliferation
rate. Single-cell RNA sequencing revealed that epidermal developmental progenitors
form a more uniform population compared with adult stem and progenitor cells.
Finally, we found that the spatial pattern of cell division orientation is dictated
locally by the underlying collagen fiber orientation. Our results uncover a simple
design principle of organ growth where progenitors and differentiated cells expand
in harmony with their surrounding tissues.
article_processing_charge: No
article_type: original
author:
- first_name: Sophie
full_name: Dekoninck, Sophie
last_name: Dekoninck
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Alejandro
full_name: Sifrim, Alejandro
last_name: Sifrim
- first_name: Yekaterina A.
full_name: Miroshnikova, Yekaterina A.
last_name: Miroshnikova
- first_name: Mariaceleste
full_name: Aragona, Mariaceleste
last_name: Aragona
- first_name: Milan
full_name: Malfait, Milan
last_name: Malfait
- first_name: Souhir
full_name: Gargouri, Souhir
last_name: Gargouri
- first_name: Charlotte
full_name: De Neunheuser, Charlotte
last_name: De Neunheuser
- first_name: Christine
full_name: Dubois, Christine
last_name: Dubois
- first_name: Thierry
full_name: Voet, Thierry
last_name: Voet
- first_name: Sara A.
full_name: Wickström, Sara A.
last_name: Wickström
- first_name: Benjamin D.
full_name: Simons, Benjamin D.
last_name: Simons
- first_name: Cédric
full_name: Blanpain, Cédric
last_name: Blanpain
citation:
ama: Dekoninck S, Hannezo EB, Sifrim A, et al. Defining the design principles of
skin epidermis postnatal growth. Cell. 2020;181(3):604-620.e22. doi:10.1016/j.cell.2020.03.015
apa: Dekoninck, S., Hannezo, E. B., Sifrim, A., Miroshnikova, Y. A., Aragona, M.,
Malfait, M., … Blanpain, C. (2020). Defining the design principles of skin epidermis
postnatal growth. Cell. Elsevier. https://doi.org/10.1016/j.cell.2020.03.015
chicago: Dekoninck, Sophie, Edouard B Hannezo, Alejandro Sifrim, Yekaterina A. Miroshnikova,
Mariaceleste Aragona, Milan Malfait, Souhir Gargouri, et al. “Defining the Design
Principles of Skin Epidermis Postnatal Growth.” Cell. Elsevier, 2020. https://doi.org/10.1016/j.cell.2020.03.015.
ieee: S. Dekoninck et al., “Defining the design principles of skin epidermis
postnatal growth,” Cell, vol. 181, no. 3. Elsevier, p. 604–620.e22, 2020.
ista: Dekoninck S, Hannezo EB, Sifrim A, Miroshnikova YA, Aragona M, Malfait M,
Gargouri S, De Neunheuser C, Dubois C, Voet T, Wickström SA, Simons BD, Blanpain
C. 2020. Defining the design principles of skin epidermis postnatal growth. Cell.
181(3), 604–620.e22.
mla: Dekoninck, Sophie, et al. “Defining the Design Principles of Skin Epidermis
Postnatal Growth.” Cell, vol. 181, no. 3, Elsevier, 2020, p. 604–620.e22,
doi:10.1016/j.cell.2020.03.015.
short: S. Dekoninck, E.B. Hannezo, A. Sifrim, Y.A. Miroshnikova, M. Aragona, M.
Malfait, S. Gargouri, C. De Neunheuser, C. Dubois, T. Voet, S.A. Wickström, B.D.
Simons, C. Blanpain, Cell 181 (2020) 604–620.e22.
date_created: 2020-05-03T22:00:48Z
date_published: 2020-04-30T00:00:00Z
date_updated: 2023-08-21T06:17:43Z
day: '30'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1016/j.cell.2020.03.015
external_id:
isi:
- '000530708400016'
pmid:
- '32259486'
file:
- access_level: open_access
checksum: e2114902f4e9d75a752e9efb5ae06011
content_type: application/pdf
creator: dernst
date_created: 2020-05-04T10:20:55Z
date_updated: 2020-07-14T12:48:03Z
file_id: '7795'
file_name: 2020_Cell_Dekoninck.pdf
file_size: 17992888
relation: main_file
file_date_updated: 2020-07-14T12:48:03Z
has_accepted_license: '1'
intvolume: ' 181'
isi: 1
issue: '3'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 604-620.e22
pmid: 1
publication: Cell
publication_identifier:
eissn:
- '10974172'
issn:
- '00928674'
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Defining the design principles of skin epidermis postnatal growth
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 181
year: '2020'
...