{"year":"2020","type":"journal_article","author":[{"last_name":"Xu","full_name":"Xu, Duo","id":"3454D55E-F248-11E8-B48F-1D18A9856A87","first_name":"Duo"},{"full_name":"Varshney, Atul","last_name":"Varshney","id":"2A2006B2-F248-11E8-B48F-1D18A9856A87","first_name":"Atul","orcid":"0000-0002-3072-5999"},{"first_name":"Xingyu","id":"34BADBA6-F248-11E8-B48F-1D18A9856A87","last_name":"Ma","full_name":"Ma, Xingyu","orcid":"0000-0002-0179-9737"},{"last_name":"Song","full_name":"Song, Baofang","first_name":"Baofang"},{"first_name":"Michael","id":"3BE60946-F248-11E8-B48F-1D18A9856A87","last_name":"Riedl","full_name":"Riedl, Michael","orcid":"0000-0003-4844-6311"},{"full_name":"Avila, Marc","last_name":"Avila","first_name":"Marc"},{"first_name":"Björn","id":"3A374330-F248-11E8-B48F-1D18A9856A87","full_name":"Hof, Björn","last_name":"Hof","orcid":"0000-0003-2057-2754"}],"department":[{"_id":"BjHo"}],"_id":"7932","title":"Nonlinear hydrodynamic instability and turbulence in pulsatile flow","date_updated":"2023-11-30T10:55:13Z","page":"11233-11239","month":"05","volume":117,"date_created":"2020-06-07T22:00:51Z","intvolume":"       117","article_type":"original","isi":1,"publication_status":"published","oa_version":"Preprint","oa":1,"day":"26","ec_funded":1,"status":"public","main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/2005.11190"}],"project":[{"name":"Instabilities in pulsating pipe flow of Newtonian and complex fluids","call_identifier":"FWF","_id":"238B8092-32DE-11EA-91FC-C7463DDC885E","grant_number":"I04188"},{"name":"ISTplus - Postdoctoral Fellowships","_id":"260C2330-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"754411"}],"date_published":"2020-05-26T00:00:00Z","publication_identifier":{"issn":["00278424"],"eissn":["10916490"]},"external_id":{"arxiv":["2005.11190"],"isi":["000536797100014"]},"quality_controlled":"1","publication":"Proceedings of the National Academy of Sciences of the United States of America","related_material":{"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/blood-flows-more-turbulent-than-previously-expected/","relation":"press_release"}],"record":[{"status":"public","id":"12726","relation":"dissertation_contains"},{"id":"14530","status":"public","relation":"dissertation_contains"}]},"article_processing_charge":"No","language":[{"iso":"eng"}],"issue":"21","abstract":[{"lang":"eng","text":"Pulsating flows through tubular geometries are laminar provided that velocities are moderate. This in particular is also believed to apply to cardiovascular flows where inertial forces are typically too low to sustain turbulence. On the other hand, flow instabilities and fluctuating shear stresses are held responsible for a variety of cardiovascular diseases. Here we report a nonlinear instability mechanism for pulsating pipe flow that gives rise to bursts of turbulence at low flow rates. Geometrical distortions of small, yet finite, amplitude are found to excite a state consisting of helical vortices during flow deceleration. The resulting flow pattern grows rapidly in magnitude, breaks down into turbulence, and eventually returns to laminar when the flow accelerates. This scenario causes shear stress fluctuations and flow reversal during each pulsation cycle. Such unsteady conditions can adversely affect blood vessels and have been shown to promote inflammation and dysfunction of the shear stress-sensitive endothelial cell layer."}],"publisher":"National Academy of Sciences","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","doi":"10.1073/pnas.1913716117","scopus_import":"1","citation":{"short":"D. Xu, A. Varshney, X. Ma, B. Song, M. Riedl, M. Avila, B. Hof, Proceedings of the National Academy of Sciences of the United States of America 117 (2020) 11233–11239.","apa":"Xu, D., Varshney, A., Ma, X., Song, B., Riedl, M., Avila, M., &#38; Hof, B. (2020). Nonlinear hydrodynamic instability and turbulence in pulsatile flow. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences. <a href=\"https://doi.org/10.1073/pnas.1913716117\">https://doi.org/10.1073/pnas.1913716117</a>","mla":"Xu, Duo, et al. “Nonlinear Hydrodynamic Instability and Turbulence in Pulsatile Flow.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 117, no. 21, National Academy of Sciences, 2020, pp. 11233–39, doi:<a href=\"https://doi.org/10.1073/pnas.1913716117\">10.1073/pnas.1913716117</a>.","ista":"Xu D, Varshney A, Ma X, Song B, Riedl M, Avila M, Hof B. 2020. Nonlinear hydrodynamic instability and turbulence in pulsatile flow. Proceedings of the National Academy of Sciences of the United States of America. 117(21), 11233–11239.","ieee":"D. Xu <i>et al.</i>, “Nonlinear hydrodynamic instability and turbulence in pulsatile flow,” <i>Proceedings of the National Academy of Sciences of the United States of America</i>, vol. 117, no. 21. National Academy of Sciences, pp. 11233–11239, 2020.","ama":"Xu D, Varshney A, Ma X, et al. Nonlinear hydrodynamic instability and turbulence in pulsatile flow. <i>Proceedings of the National Academy of Sciences of the United States of America</i>. 2020;117(21):11233-11239. doi:<a href=\"https://doi.org/10.1073/pnas.1913716117\">10.1073/pnas.1913716117</a>","chicago":"Xu, Duo, Atul Varshney, Xingyu Ma, Baofang Song, Michael Riedl, Marc Avila, and Björn Hof. “Nonlinear Hydrodynamic Instability and Turbulence in Pulsatile Flow.” <i>Proceedings of the National Academy of Sciences of the United States of America</i>. National Academy of Sciences, 2020. <a href=\"https://doi.org/10.1073/pnas.1913716117\">https://doi.org/10.1073/pnas.1913716117</a>."}}