TY - JOUR AB - Peptides derived from non-functional precursors play important roles in various developmental processes, but also in (a)biotic stress signaling. Our (phospho)proteome-wide analyses of C-terminally encoded peptide 5 (CEP5)-mediated changes revealed an impact on abiotic stress-related processes. Drought has a dramatic impact on plant growth, development and reproduction, and the plant hormone auxin plays a role in drought responses. Our genetic, physiological, biochemical and pharmacological results demonstrated that CEP5-mediated signaling is relevant for osmotic and drought stress tolerance in Arabidopsis, and that CEP5 specifically counteracts auxin effects. Specifically, we found that CEP5 signaling stabilizes AUX/IAA transcriptional repressors, suggesting the existence of a novel peptide-dependent control mechanism that tunes auxin signaling. These observations align with the recently described role of AUX/IAAs in stress tolerance and provide a novel role for CEP5 in osmotic and drought stress tolerance. AU - Smith, S AU - Zhu, S AU - Joos, L AU - Roberts, I AU - Nikonorova, N AU - Vu, LD AU - Stes, E AU - Cho, H AU - Larrieu, A AU - Xuan, W AU - Goodall, B AU - van de Cotte, B AU - Waite, JM AU - Rigal, A AU - R Harborough, SR AU - Persiau, G AU - Vanneste, S AU - Kirschner, GK AU - Vandermarliere, E AU - Martens, L AU - Stahl, Y AU - Audenaert, D AU - Friml, Jiří AU - Felix, G AU - Simon, R AU - Bennett, M AU - Bishopp, A AU - De Jaeger, G AU - Ljung, K AU - Kepinski, S AU - Robert, S AU - Nemhauser, J AU - Hwang, I AU - Gevaert, K AU - Beeckman, T AU - De Smet, I ID - 7949 IS - 8 JF - Molecular & Cellular Proteomics TI - The CEP5 peptide promotes abiotic stress tolerance, as revealed by quantitative proteomics, and attenuates the AUX/IAA equilibrium in Arabidopsis VL - 19 ER -