---
res:
  bibo_abstract:
  - Linking epigenetic marks to clinical outcomes improves insight into molecular
    processes, disease prediction, and therapeutic target identification. Here, a
    statistical approach is presented to infer the epigenetic architecture of complex
    disease, determine the variation captured by epigenetic effects, and estimate
    phenotype-epigenetic probe associations jointly. Implicitly adjusting for probe
    correlations, data structure (cell-count or relatedness), and single-nucleotide
    polymorphism (SNP) marker effects, improves association estimates and in 9,448
    individuals, 75.7% (95% CI 71.70–79.3) of body mass index (BMI) variation and
    45.6% (95% CI 37.3–51.9) of cigarette consumption variation was captured by whole
    blood methylation array data. Pathway-linked probes of blood cholesterol, lipid
    transport and sterol metabolism for BMI, and xenobiotic stimuli response for smoking,
    showed >1.5 times larger associations with >95% posterior inclusion probability.
    Prediction accuracy improved by 28.7% for BMI and 10.2% for smoking over a LASSO
    model, with age-, and tissue-specificity, implying associations are a phenotypic
    consequence rather than causal. @eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: D
      foaf_name: Trejo Banos, D
      foaf_surname: Trejo Banos
  - foaf_Person:
      foaf_givenName: DL
      foaf_name: McCartney, DL
      foaf_surname: McCartney
  - foaf_Person:
      foaf_givenName: M
      foaf_name: Patxot, M
      foaf_surname: Patxot
  - foaf_Person:
      foaf_givenName: L
      foaf_name: Anchieri, L
      foaf_surname: Anchieri
  - foaf_Person:
      foaf_givenName: T
      foaf_name: Battram, T
      foaf_surname: Battram
  - foaf_Person:
      foaf_givenName: C
      foaf_name: Christiansen, C
      foaf_surname: Christiansen
  - foaf_Person:
      foaf_givenName: R
      foaf_name: Costeira, R
      foaf_surname: Costeira
  - foaf_Person:
      foaf_givenName: RM
      foaf_name: Walker, RM
      foaf_surname: Walker
  - foaf_Person:
      foaf_givenName: SW
      foaf_name: Morris, SW
      foaf_surname: Morris
  - foaf_Person:
      foaf_givenName: A
      foaf_name: Campbell, A
      foaf_surname: Campbell
  - foaf_Person:
      foaf_givenName: Q
      foaf_name: Zhang, Q
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: DJ
      foaf_name: Porteous, DJ
      foaf_surname: Porteous
  - foaf_Person:
      foaf_givenName: AF
      foaf_name: McRae, AF
      foaf_surname: McRae
  - foaf_Person:
      foaf_givenName: NR
      foaf_name: Wray, NR
      foaf_surname: Wray
  - foaf_Person:
      foaf_givenName: PM
      foaf_name: Visscher, PM
      foaf_surname: Visscher
  - foaf_Person:
      foaf_givenName: CS
      foaf_name: Haley, CS
      foaf_surname: Haley
  - foaf_Person:
      foaf_givenName: KL
      foaf_name: Evans, KL
      foaf_surname: Evans
  - foaf_Person:
      foaf_givenName: IJ
      foaf_name: Deary, IJ
      foaf_surname: Deary
  - foaf_Person:
      foaf_givenName: AM
      foaf_name: McIntosh, AM
      foaf_surname: McIntosh
  - foaf_Person:
      foaf_givenName: G
      foaf_name: Hemani, G
      foaf_surname: Hemani
  - foaf_Person:
      foaf_givenName: JT
      foaf_name: Bell, JT
      foaf_surname: Bell
  - foaf_Person:
      foaf_givenName: RE
      foaf_name: Marioni, RE
      foaf_surname: Marioni
  - foaf_Person:
      foaf_givenName: Matthew Richard
      foaf_name: Robinson, Matthew Richard
      foaf_surname: Robinson
      foaf_workInfoHomepage: http://www.librecat.org/personId=E5D42276-F5DA-11E9-8E24-6303E6697425
    orcid: 0000-0001-8982-8813
  bibo_doi: 10.1038/s41467-020-16520-1
  bibo_volume: 11
  dct_date: 2020^xs_gYear
  dct_identifier:
  - UT:000541702400004
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Bayesian reassessment of the epigenetic architecture of complex traits@
  fabio_hasPubmedId: '32513961'
...