---
_id: '8025'
abstract:
- lang: eng
  text: Chandelier (axoaxonic) cells (ChCs) are a distinct group of GABAergic interneurons
    that innervate the axon initial segments of pyramidal cells. However, their circuit
    role and the function of their clearly defined anatomical specificity remain unclear.
    Recent work has demonstrated that chandelier cells can produce depolarizing GABAergic
    PSPs, occasionally driving postsynaptic targets to spike. On the other hand, other
    work suggests that ChCs are hyperpolarizing and may have an inhibitory role. These
    disparate functional effects may reflect heterogeneity among ChCs. Here, using
    brain slices from transgenic mouse strains, we first demonstrate that, across
    different neocortical areas and genetic backgrounds, upper Layer 2/3 ChCs belong
    to a single electrophysiologically and morphologically defined population, extensively
    sampling Layer 1 inputs with asymmetric dendrites. Consistent with being a single
    cell type, we find electrical coupling between ChCs. We then investigate the effect
    of chandelier cell activation on pyramidal neuron spiking in several conditions,
    ranging from the resting membrane potential to stimuli designed to approximate
    in vivo membrane potential dynamics. We find that under quiescent conditions,
    chandelier cells are capable of both promoting and inhibiting spike generation,
    depending on the postsynaptic membrane potential. However, during in vivo-like
    membrane potential fluctuations, the dominant postsynaptic effect was a strong
    inhibition. Thus, neocortical chandelier cells, even from within a homogeneous
    population, appear to play a dual role in the circuit, helping to activate quiescent
    pyramidal neurons, while at the same time inhibiting active ones.
article_processing_charge: No
article_type: original
author:
- first_name: A. R.
  full_name: Woodruff, A. R.
  last_name: Woodruff
- first_name: L. M.
  full_name: McGarry, L. M.
  last_name: McGarry
- first_name: Tim P
  full_name: Vogels, Tim P
  id: CB6FF8D2-008F-11EA-8E08-2637E6697425
  last_name: Vogels
  orcid: 0000-0003-3295-6181
- first_name: M.
  full_name: Inan, M.
  last_name: Inan
- first_name: S. A.
  full_name: Anderson, S. A.
  last_name: Anderson
- first_name: R.
  full_name: Yuste, R.
  last_name: Yuste
citation:
  ama: Woodruff AR, McGarry LM, Vogels TP, Inan M, Anderson SA, Yuste R. State-dependent
    function of neocortical chandelier cells. <i>Journal of Neuroscience</i>. 2011;31(49):17872-17886.
    doi:<a href="https://doi.org/10.1523/jneurosci.3894-11.2011">10.1523/jneurosci.3894-11.2011</a>
  apa: Woodruff, A. R., McGarry, L. M., Vogels, T. P., Inan, M., Anderson, S. A.,
    &#38; Yuste, R. (2011). State-dependent function of neocortical chandelier cells.
    <i>Journal of Neuroscience</i>. Society for Neuroscience. <a href="https://doi.org/10.1523/jneurosci.3894-11.2011">https://doi.org/10.1523/jneurosci.3894-11.2011</a>
  chicago: Woodruff, A. R., L. M. McGarry, Tim P Vogels, M. Inan, S. A. Anderson,
    and R. Yuste. “State-Dependent Function of Neocortical Chandelier Cells.” <i>Journal
    of Neuroscience</i>. Society for Neuroscience, 2011. <a href="https://doi.org/10.1523/jneurosci.3894-11.2011">https://doi.org/10.1523/jneurosci.3894-11.2011</a>.
  ieee: A. R. Woodruff, L. M. McGarry, T. P. Vogels, M. Inan, S. A. Anderson, and
    R. Yuste, “State-dependent function of neocortical chandelier cells,” <i>Journal
    of Neuroscience</i>, vol. 31, no. 49. Society for Neuroscience, pp. 17872–17886,
    2011.
  ista: Woodruff AR, McGarry LM, Vogels TP, Inan M, Anderson SA, Yuste R. 2011. State-dependent
    function of neocortical chandelier cells. Journal of Neuroscience. 31(49), 17872–17886.
  mla: Woodruff, A. R., et al. “State-Dependent Function of Neocortical Chandelier
    Cells.” <i>Journal of Neuroscience</i>, vol. 31, no. 49, Society for Neuroscience,
    2011, pp. 17872–86, doi:<a href="https://doi.org/10.1523/jneurosci.3894-11.2011">10.1523/jneurosci.3894-11.2011</a>.
  short: A.R. Woodruff, L.M. McGarry, T.P. Vogels, M. Inan, S.A. Anderson, R. Yuste,
    Journal of Neuroscience 31 (2011) 17872–17886.
date_created: 2020-06-25T13:09:49Z
date_published: 2011-12-07T00:00:00Z
date_updated: 2021-01-12T08:16:36Z
day: '7'
doi: 10.1523/jneurosci.3894-11.2011
extern: '1'
external_id:
  pmid:
  - '22159102'
intvolume: '        31'
issue: '49'
language:
- iso: eng
main_file_link:
- open_access: '1'
  url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071969/
month: '12'
oa: 1
oa_version: Published Version
page: 17872-17886
pmid: 1
publication: Journal of Neuroscience
publication_identifier:
  issn:
  - 0270-6474
  - 1529-2401
publication_status: published
publisher: Society for Neuroscience
quality_controlled: '1'
status: public
title: State-dependent function of neocortical chandelier cells
type: journal_article
user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425
volume: 31
year: '2011'
...