[{"uri_base":"https://research-explorer.ista.ac.at","page":"171-190","date_created":"2020-07-05T15:24:51Z","date_published":"2020-01-02T00:00:00Z","isi":1,"has_accepted_license":"1","dc":{"relation":["info:eu-repo/semantics/altIdentifier/doi/10.1523/jneurosci.1278-19.2019","info:eu-repo/semantics/altIdentifier/issn/0270-6474","info:eu-repo/semantics/altIdentifier/issn/1529-2401","info:eu-repo/semantics/altIdentifier/wos/000505167600016","info:eu-repo/semantics/altIdentifier/pmid/31694962","info:eu-repo/grantAgreement/EC/H2020/754411"],"source":["Lombardi F, Gómez-Extremera M, Bernaola-Galván P, et al. Critical dynamics and coupling in bursts of cortical rhythms indicate non-homeostatic mechanism for sleep-stage transitions and dual role of VLPO neurons in both sleep and wake. Journal of Neuroscience. 2020;40(1):171-190. doi:10.1523/jneurosci.1278-19.2019"],"description":["Origin and functions of intermittent transitions among sleep stages, including brief awakenings and arousals, constitute a challenge to the current homeostatic framework for sleep regulation, focusing on factors modulating sleep over large time scales. Here we propose that the complex micro-architecture characterizing sleep on scales of seconds and minutes results from intrinsic non-equilibrium critical dynamics. We investigate θ- and δ-wave dynamics in control rats and in rats where the sleep-promoting ventrolateral preoptic nucleus (VLPO) is lesioned (male Sprague-Dawley rats). We demonstrate that bursts in θ and δ cortical rhythms exhibit complex temporal organization, with long-range correlations and robust duality of power-law (θ-bursts, active phase) and exponential-like (δ-bursts, quiescent phase) duration distributions, features typical of non-equilibrium systems self-organizing at criticality. We show that such non-equilibrium behavior relates to anti-correlated coupling between θ- and δ-bursts, persists across a range of time scales, and is independent of the dominant physiologic state; indications of a basic principle in sleep regulation. Further, we find that VLPO lesions lead to a modulation of cortical dynamics resulting in altered dynamical parameters of θ- and δ-bursts and significant reduction in θ–δ coupling. Our empirical findings and model simulations demonstrate that θ–δ coupling is essential for the emerging non-equilibrium critical dynamics observed across the sleep–wake cycle, and indicate that VLPO neurons may have dual role for both sleep and arousal/brief wake activation. The uncovered critical behavior in sleep- and wake-related cortical rhythms indicates a mechanism essential for the micro-architecture of spontaneous sleep-stage and arousal transitions within a novel, non-homeostatic paradigm of sleep regulation."],"identifier":["https://research-explorer.ista.ac.at/record/8084","https://research-explorer.ista.ac.at/download/8084/8150"],"date":["2020"],"publisher":["Society for Neuroscience"],"type":["info:eu-repo/semantics/article","doc-type:article","text","http://purl.org/coar/resource_type/c_6501"],"rights":["info:eu-repo/semantics/openAccess"],"language":["eng"],"creator":["Lombardi, Fabrizio","Gómez-Extremera, Manuel","Bernaola-Galván, Pedro","Vetrivelan, Ramalingam","Saper, Clifford B.","Scammell, Thomas E.","Ivanov, Plamen Ch."],"subject":["ddc:570"],"title":["Critical dynamics and coupling in bursts of cortical rhythms indicate non-homeostatic mechanism for sleep-stage transitions and dual role of VLPO neurons in both sleep and wake"]},"publication":"Journal of Neuroscience","day":"02","oa":1,"quality_controlled":"1","external_id":{"pmid":[],"isi":[]},"article_processing_charge":"No","author":[{"id":"A057D288-3E88-11E9-986D-0CF4E5697425","first_name":"Fabrizio","orcid":"0000-0003-2623-5249","last_name":"Lombardi"},{"first_name":"Manuel","last_name":"Gómez-Extremera"},{"last_name":"Bernaola-Galván","first_name":"Pedro"},{"first_name":"Ramalingam","last_name":"Vetrivelan"},{"first_name":"Clifford B.","last_name":"Saper"},{"last_name":"Scammell","first_name":"Thomas E."},{"last_name":"Ivanov","first_name":"Plamen Ch."}],"dini_type":"doc-type:article","citation":{"chicago":"Lombardi, Fabrizio, Manuel Gómez-Extremera, Pedro Bernaola-Galván, Ramalingam Vetrivelan, Clifford B. Saper, Thomas E. Scammell, and Plamen Ch. Ivanov. “Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake.” Journal of Neuroscience. Society for Neuroscience, 2020. https://doi.org/10.1523/jneurosci.1278-19.2019.","ista":"Lombardi F, Gómez-Extremera M, Bernaola-Galván P, Vetrivelan R, Saper CB, Scammell TE, Ivanov PC. 2020. Critical dynamics and coupling in bursts of cortical rhythms indicate non-homeostatic mechanism for sleep-stage transitions and dual role of VLPO neurons in both sleep and wake. Journal of Neuroscience. 40(1), 171–190.","mla":"Lombardi, Fabrizio, et al. “Critical Dynamics and Coupling in Bursts of Cortical Rhythms Indicate Non-Homeostatic Mechanism for Sleep-Stage Transitions and Dual Role of VLPO Neurons in Both Sleep and Wake.” Journal of Neuroscience, vol. 40, no. 1, Society for Neuroscience, 2020, pp. 171–90, doi:10.1523/jneurosci.1278-19.2019.","apa":"Lombardi, F., Gómez-Extremera, M., Bernaola-Galván, P., Vetrivelan, R., Saper, C. B., Scammell, T. E., & Ivanov, P. C. (2020). Critical dynamics and coupling in bursts of cortical rhythms indicate non-homeostatic mechanism for sleep-stage transitions and dual role of VLPO neurons in both sleep and wake. Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/jneurosci.1278-19.2019","short":"F. Lombardi, M. Gómez-Extremera, P. Bernaola-Galván, R. Vetrivelan, C.B. Saper, T.E. Scammell, P.C. Ivanov, Journal of Neuroscience 40 (2020) 171–190.","ieee":"F. Lombardi et al., “Critical dynamics and coupling in bursts of cortical rhythms indicate non-homeostatic mechanism for sleep-stage transitions and dual role of VLPO neurons in both sleep and wake,” Journal of Neuroscience, vol. 40, no. 1. Society for Neuroscience, pp. 171–190, 2020."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","project":[{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"ec_funded":1,"issue":"1","volume":40,"publication_status":"published","publication_identifier":{"eissn":[],"issn":[]},"language":[{}],"file":[{"file_name":"2020_JournNeuroscience_Lombardi.pdf","date_created":"2020-07-22T11:44:48Z","creator":"dernst","file_size":6646046,"date_updated":"2020-07-22T11:44:48Z","success":1,"file_id":"8150","relation":"main_file","access_level":"open_access","content_type":"application/pdf"}],"scopus_import":"1","intvolume":" 40","month":"01","abstract":[{"lang":"eng"}],"pmid":1,"oa_version":"Published Version","file_date_updated":"2020-07-22T11:44:48Z","department":[{"_id":"GaTk","tree":[{"_id":"ResearchGroups"},{"_id":"IST"}]}],"date_updated":"2023-09-05T14:02:55Z","ddc":[],"creator":{"login":"flombard","id":"A057D288-3E88-11E9-986D-0CF4E5697425"},"type":"journal_article","article_type":"original","status":"public","_id":"8084"}]