---
res:
  bibo_abstract:
  - The assembly of HIV-1 is mediated by oligomerization of the major structural polyprotein,
    Gag, into a hexameric protein lattice at the plasma membrane of the infected cell.
    This leads to budding and release of progeny immature virus particles. Subsequent
    proteolytic cleavage of Gag triggers rearrangement of the particles to form mature
    infectious virions. Obtaining a structural model of the assembled lattice of Gag
    within immature virus particles is necessary to understand the interactions that
    mediate assembly of HIV-1 particles in the infected cell, and to describe the
    substrate that is subsequently cleaved by the viral protease. An 8-Å resolution
    structure of an immature virus-like tubular array assembled from a Gag-derived
    protein of the related retrovirus Mason-Pfizer monkey virus (M-PMV) has previously
    been reported, and a model for the arrangement of the HIV-1 capsid (CA) domains
    has been generated based on homology to this structure. Here we have assembled
    tubular arrays of a HIV-1 Gag-derived protein with an immature-like arrangement
    of the C-terminal CA domains and have solved their structure by using hybrid cryo-EM
    and tomography analysis. The structure reveals the arrangement of the C-terminal
    domain of CA within an immature-like HIV-1 Gag lattice, and provides, to our knowledge,
    the first high-resolution view of the region immediately downstream of CA, which
    is essential for assembly, and is significantly different from the respective
    region in M-PMV. Our results reveal a hollow column of density for this region
    in HIV-1 that is compatible with the presence of a six-helix bundle at this position.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Tanmay
      foaf_name: Bharata, Tanmay A
      foaf_surname: Bharata
  - foaf_Person:
      foaf_givenName: Luis
      foaf_name: Menendez, Luis R
      foaf_surname: Menendez
  - foaf_Person:
      foaf_givenName: Wim
      foaf_name: Hagena, Wim J
      foaf_surname: Hagena
  - foaf_Person:
      foaf_givenName: Vanda
      foaf_name: Luxd, Vanda
      foaf_surname: Luxd
  - foaf_Person:
      foaf_givenName: Sebastien
      foaf_name: Igonete, Sebastien
      foaf_surname: Igonete
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Schorba, Martin
      foaf_surname: Schorba
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Florian Schur
      foaf_surname: Schur
      foaf_workInfoHomepage: http://www.librecat.org/personId=48AD8942-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4790-8078
  - foaf_Person:
      foaf_givenName: Hans
      foaf_name: Kraüsslich, Hans Georg
      foaf_surname: Kraüsslich
  - foaf_Person:
      foaf_givenName: John
      foaf_name: Briggsa, John A
      foaf_surname: Briggsa
  bibo_doi: 10.1073/pnas.1401455111
  bibo_issue: '22'
  bibo_volume: 111
  dct_date: 2014^xs_gYear
  dct_publisher: National Academy of Sciences@
  dct_title: Cryo electron microscopy of tubular arrays of HIV-1 Gag resolves structures
    essential for immature virus assembly@
...