---
res:
  bibo_abstract:
  - Lamellipodia are sheet-like protrusions formed during migration or phagocytosis
    and comprise a network of actin filaments. Filament formation in this network
    is initiated by nucleation/branching through the actin-related protein 2/3 (Arp2/3)
    complex downstream of its activator, suppressor of cAMP receptor/WASP-family verprolin
    homologous (Scar/WAVE), but the relative relevance of Arp2/3-mediated branching
    versus actin filament elongation is unknown. Here we use instantaneous interference
    with Arp2/3 complex function in live fibroblasts with established lamellipodia.
    This allows direct examination of both the fate of elongating filaments upon instantaneous
    suppression of Arp2/3 complex activity and the consequences of this treatment
    on the dynamics of other lamellipodial regulators. We show that Arp2/3 complex
    is an essential organizer of treadmilling actin filament arrays but has little
    effect on the net rate of actin filament turnover at the cell periphery. In addition,
    Arp2/3 complex serves as key upstream factor for the recruitment of modulators
    of lamellipodia formation such as capping protein or cofilin. Arp2/3 complex is
    thus decisive for filament organization and geometry within the network not only
    by generating branches and novel filament ends, but also by directing capping
    or severing activities to the lamellipodium. Arp2/3 complex is also crucial to
    lamellipodia-based migration of keratocytes.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Stefan
      foaf_name: Koestler, Stefan A
      foaf_surname: Koestler
  - foaf_Person:
      foaf_givenName: Anika
      foaf_name: Steffen, Anika
      foaf_surname: Steffen
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Maria Nemethova
      foaf_surname: Nemethova
      foaf_workInfoHomepage: http://www.librecat.org/personId=34E27F1C-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Moritz
      foaf_name: Winterhoff, Moritz
      foaf_surname: Winterhoff
  - foaf_Person:
      foaf_givenName: Ningning
      foaf_name: Luo, Ningning
      foaf_surname: Luo
  - foaf_Person:
      foaf_givenName: J.
      foaf_name: Holleboom, J. Margit
      foaf_surname: Holleboom
  - foaf_Person:
      foaf_givenName: Jessica
      foaf_name: Krupp, Jessica
      foaf_surname: Krupp
  - foaf_Person:
      foaf_givenName: Sonja
      foaf_name: Jacob, Sonja
      foaf_surname: Jacob
  - foaf_Person:
      foaf_givenName: Marlene
      foaf_name: Vinzenz, Marlene
      foaf_surname: Vinzenz
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Florian Schur
      foaf_surname: Schur
      foaf_workInfoHomepage: http://www.librecat.org/personId=48AD8942-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4790-8078
  - foaf_Person:
      foaf_givenName: Kai
      foaf_name: Schlüter, Kai
      foaf_surname: Schlüter
  - foaf_Person:
      foaf_givenName: Peter
      foaf_name: Gunning, Peter W
      foaf_surname: Gunning
  - foaf_Person:
      foaf_givenName: Christoph
      foaf_name: Winkler, Christoph
      foaf_surname: Winkler
  - foaf_Person:
      foaf_givenName: Christian
      foaf_name: Schmeiser, Christian
      foaf_surname: Schmeiser
  - foaf_Person:
      foaf_givenName: Jan
      foaf_name: Faix, Jan
      foaf_surname: Faix
  - foaf_Person:
      foaf_givenName: Theresia
      foaf_name: Stradal, Theresia E
      foaf_surname: Stradal
  - foaf_Person:
      foaf_givenName: John
      foaf_name: Small, John V
      foaf_surname: Small
  - foaf_Person:
      foaf_givenName: Klemens
      foaf_name: Rottner, Klemens
      foaf_surname: Rottner
  bibo_doi: 10.1091/mbc.E12-12-0857
  bibo_issue: '18'
  bibo_volume: 24
  dct_date: 2013^xs_gYear
  dct_publisher: American Society for Biology@
  dct_title: Arp2/3 complex is essential for actin network treadmilling as well as
    for targeting of capping protein and cofilin@
...