--- res: bibo_abstract: - The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Claudia foaf_name: Clopath, Claudia foaf_surname: Clopath - foaf_Person: foaf_givenName: Tim P foaf_name: Vogels, Tim P foaf_surname: Vogels foaf_workInfoHomepage: http://www.librecat.org/personId=CB6FF8D2-008F-11EA-8E08-2637E6697425 orcid: 0000-0003-3295-6181 - foaf_Person: foaf_givenName: Robert C. foaf_name: Froemke, Robert C. foaf_surname: Froemke - foaf_Person: foaf_givenName: Henning foaf_name: Sprekeler, Henning foaf_surname: Sprekeler dct_date: 2016^xs_gYear dct_language: eng dct_publisher: Cold Spring Harbor Laboratory@ dct_title: Receptive field formation by interacting excitatory and inhibitory synaptic plasticity@ ...