[{"dini_type":"doc-type:preprint","oa":1,"extern":"1","language":[{}],"publication":"bioRxiv","author":[{"last_name":"Clopath","first_name":"Claudia"},{"orcid":"0000-0003-3295-6181","first_name":"Tim P","id":"CB6FF8D2-008F-11EA-8E08-2637E6697425","last_name":"Vogels"},{"last_name":"Froemke","first_name":"Robert C."},{"last_name":"Sprekeler","first_name":"Henning"}],"date_created":"2020-07-16T12:26:55Z","creator":{"id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","login":"cziletti"},"citation":{"short":"C. Clopath, T.P. Vogels, R.C. Froemke, H. Sprekeler, BioRxiv (2016).","apa":"Clopath, C., Vogels, T. P., Froemke, R. C., & Sprekeler, H. (2016). Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv. Cold Spring Harbor Laboratory.","ieee":"C. Clopath, T. P. Vogels, R. C. Froemke, and H. Sprekeler, “Receptive field formation by interacting excitatory and inhibitory synaptic plasticity,” bioRxiv. Cold Spring Harbor Laboratory, 2016.","mla":"Clopath, Claudia, et al. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” BioRxiv, Cold Spring Harbor Laboratory, 2016.","chicago":"Clopath, Claudia, Tim P Vogels, Robert C. Froemke, and Henning Sprekeler. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” BioRxiv. Cold Spring Harbor Laboratory, 2016.","ista":"Clopath C, Vogels TP, Froemke RC, Sprekeler H. 2016. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv, ."},"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1101/066589 "}],"oa_version":"Preprint","publication_status":"published","status":"public","user_id":"D865714E-FA4E-11E9-B85B-F5C5E5697425","type":"preprint","_id":"8128","dc":{"publisher":["Cold Spring Harbor Laboratory"],"type":["info:eu-repo/semantics/preprint","doc-type:preprint","text","http://purl.org/coar/resource_type/c_816b"],"title":["Receptive field formation by interacting excitatory and inhibitory synaptic plasticity"],"source":["Clopath C, Vogels TP, Froemke RC, Sprekeler H. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv. 2016."],"creator":["Clopath, Claudia","Vogels, Tim P","Froemke, Robert C.","Sprekeler, Henning"],"rights":["info:eu-repo/semantics/openAccess"],"date":["2016"],"description":["The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex."],"identifier":["https://research-explorer.ista.ac.at/record/8128"],"language":["eng"]},"article_processing_charge":"No","page":"43","uri_base":"https://research-explorer.ista.ac.at","abstract":[{"lang":"eng"}],"month":"07","date_published":"2016-07-29T00:00:00Z","date_updated":"2021-01-12T08:17:02Z","day":"29"}]