--- _id: '8128' abstract: - lang: eng text: The stimulus selectivity of synaptic currents in cortical neurons often shows a co-tuning of excitation and inhibition, but the mechanisms that underlie the emergence and plasticity of this co-tuning are not fully understood. Using a computational model, we show that an interaction of excitatory and inhibitory synaptic plasticity reproduces both the developmental and – when combined with a disinhibitory gate – the adult plasticity of excitatory and inhibitory receptive fields in auditory cortex. The co-tuning arises from inhibitory plasticity that balances excitation and inhibition, while excitatory stimulus selectivity can result from two different mechanisms. Inhibitory inputs with a broad stimulus tuning introduce a sliding threshold as in Bienenstock-Cooper-Munro rules, introducing an excitatory stimulus selectivity at the cost of a broader inhibitory receptive field. Alternatively, input asymmetries can be amplified by synaptic competition. The latter leaves any receptive field plasticity transient, a prediction we verify in recordings in auditory cortex. article_processing_charge: No author: - first_name: Claudia full_name: Clopath, Claudia last_name: Clopath - first_name: Tim P full_name: Vogels, Tim P id: CB6FF8D2-008F-11EA-8E08-2637E6697425 last_name: Vogels orcid: 0000-0003-3295-6181 - first_name: Robert C. full_name: Froemke, Robert C. last_name: Froemke - first_name: Henning full_name: Sprekeler, Henning last_name: Sprekeler citation: ama: Clopath C, Vogels TP, Froemke RC, Sprekeler H. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv. 2016. apa: Clopath, C., Vogels, T. P., Froemke, R. C., & Sprekeler, H. (2016). Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv. Cold Spring Harbor Laboratory. chicago: Clopath, Claudia, Tim P Vogels, Robert C. Froemke, and Henning Sprekeler. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” BioRxiv. Cold Spring Harbor Laboratory, 2016. ieee: C. Clopath, T. P. Vogels, R. C. Froemke, and H. Sprekeler, “Receptive field formation by interacting excitatory and inhibitory synaptic plasticity,” bioRxiv. Cold Spring Harbor Laboratory, 2016. ista: Clopath C, Vogels TP, Froemke RC, Sprekeler H. 2016. Receptive field formation by interacting excitatory and inhibitory synaptic plasticity. bioRxiv, . mla: Clopath, Claudia, et al. “Receptive Field Formation by Interacting Excitatory and Inhibitory Synaptic Plasticity.” BioRxiv, Cold Spring Harbor Laboratory, 2016. short: C. Clopath, T.P. Vogels, R.C. Froemke, H. Sprekeler, BioRxiv (2016). date_created: 2020-07-16T12:26:55Z date_published: 2016-07-29T00:00:00Z date_updated: 2021-01-12T08:17:02Z day: '29' extern: '1' language: - iso: eng main_file_link: - open_access: '1' url: 'https://doi.org/10.1101/066589 ' month: '07' oa: 1 oa_version: Preprint page: '43' publication: bioRxiv publication_status: published publisher: Cold Spring Harbor Laboratory status: public title: Receptive field formation by interacting excitatory and inhibitory synaptic plasticity type: preprint user_id: D865714E-FA4E-11E9-B85B-F5C5E5697425 year: '2016' ...