---
res:
  bibo_abstract:
  - Immature HIV-1 assembles at and buds from the plasma membrane before proteolytic
    cleavage of the viral Gag polyprotein induces structural maturation. Maturation
    can be blocked by maturation inhibitors (MIs), thereby abolishing infectivity.
    The CA (capsid) and SP1 (spacer peptide 1) region of Gag is the key regulator
    of assembly and maturation and is the target of MIs.We applied optimized cryo-electron
    tomography and subtomogram averaging to resolve this region within assembled immature
    HIV-1 particles at 3.9 angstrom resolution and built an atomic model. The structure
    reveals a network of intra- And intermolecular interactions mediating immature
    HIV-1 assembly. The proteolytic cleavage site between CA and SP1 is inaccessible
    to protease.We suggest that MIs prevent CA-SP1 cleavage by stabilizing the structure,
    and MI resistance develops by destabilizing CA-SP1.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Florian
      foaf_name: Schur, Florian
      foaf_surname: Schur
      foaf_workInfoHomepage: http://www.librecat.org/personId=48AD8942-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-4790-8078
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Obr, Martin
      foaf_surname: Obr
      foaf_workInfoHomepage: http://www.librecat.org/personId=4741CA5A-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-1756-6564
  - foaf_Person:
      foaf_givenName: Wim
      foaf_name: Hagen, Wim
      foaf_surname: Hagen
  - foaf_Person:
      foaf_givenName: William
      foaf_name: Wan, William
      foaf_surname: Wan
  - foaf_Person:
      foaf_givenName: Arjen
      foaf_name: Jakobi, Arjen
      foaf_surname: Jakobi
  - foaf_Person:
      foaf_givenName: Joanna
      foaf_name: Kirkpatrick, Joanna
      foaf_surname: Kirkpatrick
  - foaf_Person:
      foaf_givenName: Carsten
      foaf_name: Sachse, Carsten
      foaf_surname: Sachse
  - foaf_Person:
      foaf_givenName: Hans
      foaf_name: Kraüsslich, Hans
      foaf_surname: Kraüsslich
  - foaf_Person:
      foaf_givenName: John
      foaf_name: Briggs, John
      foaf_surname: Briggs
  bibo_doi: 10.1126/science.aaf9620
  bibo_volume: 353
  dct_date: 2016^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0036-8075
  - http://id.crossref.org/issn/1095-9203
  dct_language: eng
  dct_publisher: American Association for the Advancement of Science@
  dct_title: An atomic model of HIV-1 capsid-SP1 reveals structures regulating assembly
    and maturation@
  fabio_hasPubmedId: '27417497'
...