---
_id: '8228'
abstract:
- lang: eng
text: "Background: Atopics have a lower risk for malignancies, and IgE targeted
to tumors is superior to IgG in fighting cancer. Whether IgE-mediated innate or
adaptive immune surveillance can confer protection against tumors remains unclear.\r\nObjective:
We aimed to investigate the effects of active and passive immunotherapy to the
tumor-associated antigen HER-2 in three murine models differing in Epsilon-B-cell-receptor
expression affecting the levels of expressed IgE.\r\nMethods: We compared the
levels of several serum specific anti-HER-2 antibodies (IgE, IgG1, IgG2a, IgG2b,
IgA) and the survival rates in low-IgE ΔM1M2 mice lacking the transmembrane/cytoplasmic
domain of Epsilon-B-cell-receptors expressing reduced IgE levels, high-IgE KN1
mice expressing chimeric Epsilon-Gamma1-B-cell receptors with 4-6-fold elevated
serum IgE levels, and wild type (WT) BALB/c. Prior engrafting mice with D2F2/E2
mammary tumors overexpressing HER-2, mice were vaccinated with HER-2 or vehicle
control PBS using the Th2-adjuvant Al(OH)3 (active immunotherapy), or treated
with the murine anti-HER-2 IgG1 antibody 4D5 (passive immunotherapy).\r\nResults:
Overall, among the three strains of mice, HER-2 vaccination induced significantly
higher levels of HER-2 specific IgE and IgG1 in high-IgE KN1, while low-IgE ΔM1M2
mice had higher IgG2a levels. HER-2 vaccination and passive immunotherapy prolonged
the survival in tumor-grafted WT and low-IgE ΔM1M2 strains compared with treatment
controls; active vaccination provided the highest benefit. Notably, untreated
high-IgE KN1 mice displayed the longest survival of all strains, which could not
be further extended by active or passive immunotherapy.\r\nConclusion: Active
and passive immunotherapies prolong survival in wild type and low-IgE ΔM1M2 mice
engrafted with mammary tumors. High-IgE KN1 mice have an innate survival benefit
following tumor challenge."
article_number: '100044'
article_processing_charge: No
article_type: original
author:
- first_name: Josef
full_name: Singer, Josef
last_name: Singer
orcid: 0000-0002-8701-2412
- first_name: Gertrude
full_name: Achatz-Straussberger, Gertrude
last_name: Achatz-Straussberger
- first_name: Anna
full_name: Bentley-Lukschal, Anna
last_name: Bentley-Lukschal
- first_name: Judit
full_name: Fazekas-Singer, Judit
id: 36432834-F248-11E8-B48F-1D18A9856A87
last_name: Fazekas-Singer
orcid: 0000-0002-8777-3502
- first_name: Gernot
full_name: Achatz, Gernot
last_name: Achatz
- first_name: Sophia N.
full_name: Karagiannis, Sophia N.
last_name: Karagiannis
- first_name: Erika
full_name: Jensen-Jarolim, Erika
last_name: Jensen-Jarolim
citation:
ama: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, et al. AllergoOncology:
High innate IgE levels are decisive for the survival of cancer-bearing mice. World
Allergy Organization Journal. 2019;12(7). doi:10.1016/j.waojou.2019.100044'
apa: 'Singer, J., Achatz-Straussberger, G., Bentley-Lukschal, A., Singer, J., Achatz,
G., Karagiannis, S. N., & Jensen-Jarolim, E. (2019). AllergoOncology: High
innate IgE levels are decisive for the survival of cancer-bearing mice. World
Allergy Organization Journal. Elsevier. https://doi.org/10.1016/j.waojou.2019.100044'
chicago: 'Singer, Josef, Gertrude Achatz-Straussberger, Anna Bentley-Lukschal, Judit
Singer, Gernot Achatz, Sophia N. Karagiannis, and Erika Jensen-Jarolim. “AllergoOncology:
High Innate IgE Levels Are Decisive for the Survival of Cancer-Bearing Mice.”
World Allergy Organization Journal. Elsevier, 2019. https://doi.org/10.1016/j.waojou.2019.100044.'
ieee: 'J. Singer et al., “AllergoOncology: High innate IgE levels are decisive
for the survival of cancer-bearing mice,” World Allergy Organization Journal,
vol. 12, no. 7. Elsevier, 2019.'
ista: 'Singer J, Achatz-Straussberger G, Bentley-Lukschal A, Singer J, Achatz G,
Karagiannis SN, Jensen-Jarolim E. 2019. AllergoOncology: High innate IgE levels
are decisive for the survival of cancer-bearing mice. World Allergy Organization
Journal. 12(7), 100044.'
mla: 'Singer, Josef, et al. “AllergoOncology: High Innate IgE Levels Are Decisive
for the Survival of Cancer-Bearing Mice.” World Allergy Organization Journal,
vol. 12, no. 7, 100044, Elsevier, 2019, doi:10.1016/j.waojou.2019.100044.'
short: J. Singer, G. Achatz-Straussberger, A. Bentley-Lukschal, J. Singer, G. Achatz,
S.N. Karagiannis, E. Jensen-Jarolim, World Allergy Organization Journal 12 (2019).
date_created: 2020-08-10T11:50:54Z
date_published: 2019-07-29T00:00:00Z
date_updated: 2021-01-12T08:17:36Z
day: '29'
doi: 10.1016/j.waojou.2019.100044
extern: '1'
intvolume: ' 12'
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.waojou.2019.100044
month: '07'
oa: 1
oa_version: Published Version
publication: World Allergy Organization Journal
publication_identifier:
issn:
- 1939-4551
publication_status: published
publisher: Elsevier
quality_controlled: '1'
status: public
title: 'AllergoOncology: High innate IgE levels are decisive for the survival of cancer-bearing
mice'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 12
year: '2019'
...