---
res:
  bibo_abstract:
  - In Arabidopsis, lateral roots originate from pericycle cells deep within the primary
    root. New lateral root primordia (LRP) have to emerge through several overlaying
    tissues. Here, we report that auxin produced in new LRP is transported towards
    the outer tissues where it triggers cell separation by inducing both the auxin
    influx carrier LAX3 and cell-wall enzymes. LAX3 is expressed in just two cell
    files overlaying new LRP. To understand how this striking pattern of LAX3 expression
    is regulated, we developed a mathematical model that captures the network regulating
    its expression and auxin transport within realistic three-dimensional cell and
    tissue geometries. Our model revealed that, for the LAX3 spatial expression to
    be robust to natural variations in root tissue geometry, an efflux carrier is
    required--later identified to be PIN3. To prevent LAX3 from being transiently
    expressed in multiple cell files, PIN3 and LAX3 must be induced consecutively,
    which we later demonstrated to be the case. Our study exemplifies how mathematical
    models can be used to direct experiments to elucidate complex developmental processes.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Benjamin
      foaf_name: Péret, Benjamin
      foaf_surname: Péret
  - foaf_Person:
      foaf_givenName: Alistair
      foaf_name: Middleton, Alistair M
      foaf_surname: Middleton
  - foaf_Person:
      foaf_givenName: Andrew
      foaf_name: French, Andrew P
      foaf_surname: French
  - foaf_Person:
      foaf_givenName: Antoine
      foaf_name: Larrieu, Antoine
      foaf_surname: Larrieu
  - foaf_Person:
      foaf_givenName: Anthony
      foaf_name: Bishopp, Anthony
      foaf_surname: Bishopp
  - foaf_Person:
      foaf_givenName: Maria
      foaf_name: Njo, Maria
      foaf_surname: Njo
  - foaf_Person:
      foaf_givenName: Darren
      foaf_name: Wells, Darren M
      foaf_surname: Wells
  - foaf_Person:
      foaf_givenName: Silvana
      foaf_name: Porco, Silvana
      foaf_surname: Porco
  - foaf_Person:
      foaf_givenName: Nathan
      foaf_name: Mellor, Nathan
      foaf_surname: Mellor
  - foaf_Person:
      foaf_givenName: Leah
      foaf_name: Band, Leah R
      foaf_surname: Band
  - foaf_Person:
      foaf_givenName: Ilda
      foaf_name: Casimiro, Ilda
      foaf_surname: Casimiro
  - foaf_Person:
      foaf_givenName: Jürgen
      foaf_name: Kleine-Vehn, Jürgen
      foaf_surname: Kleine Vehn
  - foaf_Person:
      foaf_givenName: Steffen
      foaf_name: Vanneste, Steffen
      foaf_surname: Vanneste
  - foaf_Person:
      foaf_givenName: Ilkka
      foaf_name: Sairanen, Ilkka
      foaf_surname: Sairanen
  - foaf_Person:
      foaf_givenName: Romain
      foaf_name: Mallet, Romain
      foaf_surname: Mallet
  - foaf_Person:
      foaf_givenName: Göran
      foaf_name: Sandberg, Göran
      foaf_surname: Sandberg
  - foaf_Person:
      foaf_givenName: Karin
      foaf_name: Ljung, Karin
      foaf_surname: Ljung
  - foaf_Person:
      foaf_givenName: Tom
      foaf_name: Beeckman, Tom
      foaf_surname: Beeckman
  - foaf_Person:
      foaf_givenName: Eva
      foaf_name: Eva Benková
      foaf_surname: Benková
      foaf_workInfoHomepage: http://www.librecat.org/personId=38F4F166-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8510-9739
  - foaf_Person:
      foaf_givenName: Jirí
      foaf_name: Jirí Friml
      foaf_surname: Friml
      foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-8302-7596
  - foaf_Person:
      foaf_givenName: Eric
      foaf_name: Kramer, Eric
      foaf_surname: Kramer
  - foaf_Person:
      foaf_givenName: John
      foaf_name: King, John R
      foaf_surname: King
  - foaf_Person:
      foaf_givenName: Ive
      foaf_name: De Smet, Ive
      foaf_surname: De Smet
  - foaf_Person:
      foaf_givenName: Tony
      foaf_name: Pridmore, Tony
      foaf_surname: Pridmore
  - foaf_Person:
      foaf_givenName: Markus
      foaf_name: Owen, Markus
      foaf_surname: Owen
  - foaf_Person:
      foaf_givenName: Malcolm
      foaf_name: Bennett, Malcolm J
      foaf_surname: Bennett
  bibo_doi: 10.1038/msb.2013.43
  bibo_volume: 9
  dct_date: 2013^xs_gYear
  dct_publisher: Nature Publishing Group@
  dct_title: Sequential induction of auxin efflux and influx carriers regulates lateral
    root emergence@
...