--- res: bibo_abstract: - An outstanding question in animal development, tissue homeostasis and disease is how cell populations adapt to sensory inputs. During Drosophila larval development, hematopoietic sites are in direct contact with sensory neuron clusters of the peripheral nervous system (PNS), and blood cells (hemocytes) require the PNS for their survival and recruitment to these microenvironments, known as Hematopoietic Pockets. Here we report that Activin-β, a TGF-β family ligand, is expressed by sensory neurons of the PNS and regulates the proliferation and adhesion of hemocytes. These hemocyte responses depend on PNS activity, as shown by agonist treatment and transient silencing of sensory neurons. Activin-β has a key role in this regulation, which is apparent from reporter expression and mutant analyses. This mechanism of local sensory neurons controlling blood cell adaptation invites evolutionary parallels with vertebrate hematopoietic progenitors and the independent myeloid system of tissue macrophages, whose regulation by local microenvironments remain undefined.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Kalpana foaf_name: Makhijani, Kalpana foaf_surname: Makhijani - foaf_Person: foaf_givenName: Brandy foaf_name: Alexander, Brandy foaf_surname: Alexander - foaf_Person: foaf_givenName: Deepti foaf_name: Rao, Deepti foaf_surname: Rao - foaf_Person: foaf_givenName: Sophia foaf_name: Petraki, Sophia foaf_surname: Petraki - foaf_Person: foaf_givenName: Leire foaf_name: Herboso, Leire foaf_surname: Herboso - foaf_Person: foaf_givenName: Katelyn foaf_name: Kukar, Katelyn foaf_surname: Kukar - foaf_Person: foaf_givenName: Itrat foaf_name: Batool, Itrat foaf_surname: Batool - foaf_Person: foaf_givenName: Stephanie foaf_name: Wachner, Stephanie foaf_surname: Wachner foaf_workInfoHomepage: http://www.librecat.org/personId=2A95E7B0-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Katrina foaf_name: Gold, Katrina foaf_surname: Gold - foaf_Person: foaf_givenName: Corinna foaf_name: Wong, Corinna foaf_surname: Wong - foaf_Person: foaf_givenName: Michael foaf_name: O'Connor, Michael foaf_surname: O'Connor - foaf_Person: foaf_givenName: Katja foaf_name: Brückner, Katja foaf_surname: Brückner bibo_doi: 10.1038/ncomms15990 bibo_volume: 8 dct_date: 2017^xs_gYear dct_identifier: - UT:000406360100001 dct_isPartOf: - http://id.crossref.org/issn/20411723 dct_language: eng dct_publisher: Nature Publishing Group@ dct_title: Regulation of Drosophila hematopoietic sites by Activin-β from active sensory neurons@ ...