---
res:
  bibo_abstract:
  - Biophysical investigation of membrane proteins generally requires their extraction
    from native sources using detergents, a step that can lead, possibly irreversibly,
    to protein denaturation. The propensity of dodecylphosphocholine (DPC), a detergent
    widely utilized in NMR studies of membrane proteins, to distort their structure
    has been the subject of much controversy. It has been recently proposed that the
    binding specificity of the yeast mitochondrial ADP/ATP carrier (yAAC3) toward
    cardiolipins is preserved in DPC, thereby suggesting that DPC is a suitable environment
    in which to study membrane proteins. In this communication, we used all-atom molecular
    dynamics simulations to investigate the specific binding of cardiolipins to yAAC3.
    Our data demonstrate that the interaction interface observed in a native-like
    environment differs markedly from that inferred from an NMR investigation in DPC,
    implying that in this detergent, the protein structure is distorted. We further
    investigated yAAC3 solubilized in DPC and in the milder dodecylmaltoside with
    thermal-shift assays. The loss of thermal transition observed in DPC confirms
    that the protein is no longer properly folded in this environment.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: François
      foaf_name: Dehez, François
      foaf_surname: Dehez
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Schanda, Paul
      foaf_surname: Schanda
      foaf_workInfoHomepage: http://www.librecat.org/personId=7B541462-FAF6-11E9-A490-E8DFE5697425
    orcid: 0000-0002-9350-7606
  - foaf_Person:
      foaf_givenName: Martin S.
      foaf_name: King, Martin S.
      foaf_surname: King
  - foaf_Person:
      foaf_givenName: Edmund R.S.
      foaf_name: Kunji, Edmund R.S.
      foaf_surname: Kunji
  - foaf_Person:
      foaf_givenName: Christophe
      foaf_name: Chipot, Christophe
      foaf_surname: Chipot
  bibo_doi: 10.1016/j.bpj.2017.09.019
  bibo_issue: '11'
  bibo_volume: 113
  dct_date: 2017^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0006-3495
  dct_language: eng
  dct_publisher: Elsevier@
  dct_subject:
  - Biophysics
  dct_title: Mitochondrial ADP/ATP carrier in dodecylphosphocholine binds cardiolipins
    with non-native affinity@
...