---
res:
  bibo_abstract:
  - Fast multidimensional NMR with a time resolution of a few seconds provides a new
    tool for high throughput screening and site-resolved real-time studies of kinetic
    molecular processes by NMR. Recently we have demonstrated the feasibility to record
    protein 1H–15N correlation spectra in a few seconds of acquisition time using
    a new SOFAST-HMQC experiment (Schanda and Brutscher (2005) J. Am. Chem. Soc. 127,
    8014). Here, we investigate in detail the performance of SOFAST-HMQC to record
    1H–15N and 1H−13C correlation spectra of proteins of different size and at different
    magnetic field strengths. Compared to standard 1H–15N correlation experiments
    SOFAST-HMQC provides a significant gain in sensitivity, especially for fast repetition
    rates. Guidelines are provided on how to set up SOFAST-HMQC experiments for a
    given protein sample. In addition, an alternative pulse scheme, IPAP-SOFAST-HMQC
    is presented that allows application on NMR spectrometers equipped with cryogenic
    probes, and fast measurement of one-bond 1H–13C and 1H–15N scalar and residual
    dipolar coupling constants.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Paul
      foaf_name: Schanda, Paul
      foaf_surname: Schanda
      foaf_workInfoHomepage: http://www.librecat.org/personId=7B541462-FAF6-11E9-A490-E8DFE5697425
    orcid: 0000-0002-9350-7606
  - foaf_Person:
      foaf_givenName: Ēriks
      foaf_name: Kupče, Ēriks
      foaf_surname: Kupče
  - foaf_Person:
      foaf_givenName: Bernhard
      foaf_name: Brutscher, Bernhard
      foaf_surname: Brutscher
  bibo_doi: 10.1007/s10858-005-4425-x
  bibo_issue: '4'
  bibo_volume: 33
  dct_date: 2005^xs_gYear
  dct_isPartOf:
  - http://id.crossref.org/issn/0925-2738
  - http://id.crossref.org/issn/1573-5001
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_subject:
  - Spectroscopy
  - Biochemistry
  dct_title: SOFAST-HMQC experiments for recording two-dimensional deteronuclear correlation
    spectra of proteins within a few seconds@
...