---
res:
  bibo_abstract:
  - Concerted radial migration of newly born cortical projection neurons, from their
    birthplace to their final target lamina, is a key step in the assembly of the
    cerebral cortex. The cellular and molecular mechanisms regulating the specific
    sequential steps of radial neuronal migration in vivo are however still unclear,
    let alone the effects and interactions with the extracellular environment. In
    any in vivo context, cells will always be exposed to a complex extracellular environment
    consisting of (1) secreted factors acting as potential signaling cues, (2) the
    extracellular matrix, and (3) other cells providing cell–cell interaction through
    receptors and/or direct physical stimuli. Most studies so far have described and
    focused mainly on intrinsic cell-autonomous gene functions in neuronal migration
    but there is accumulating evidence that non-cell-autonomous-, local-, systemic-,
    and/or whole tissue-wide effects substantially contribute to the regulation of
    radial neuronal migration. These non-cell-autonomous effects may differentially
    affect cortical neuron migration in distinct cellular environments. However, the
    cellular and molecular natures of such non-cell-autonomous mechanisms are mostly
    unknown. Furthermore, physical forces due to collective migration and/or community
    effects (i.e., interactions with surrounding cells) may play important roles in
    neocortical projection neuron migration. In this concise review, we first outline
    distinct models of non-cell-autonomous interactions of cortical projection neurons
    along their radial migration trajectory during development. We then summarize
    experimental assays and platforms that can be utilized to visualize and potentially
    probe non-cell-autonomous mechanisms. Lastly, we define key questions to address
    in the future.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Andi H
      foaf_name: Hansen, Andi H
      foaf_surname: Hansen
      foaf_workInfoHomepage: http://www.librecat.org/personId=38853E16-F248-11E8-B48F-1D18A9856A87
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  bibo_doi: 10.3389/fcell.2020.574382
  bibo_issue: '9'
  bibo_volume: 8
  dct_date: 2020^xs_gYear
  dct_identifier:
  - UT:000577915900001
  dct_isPartOf:
  - http://id.crossref.org/issn/2296-634X
  dct_language: eng
  dct_publisher: Frontiers@
  dct_title: Non-cell-autonomous mechanisms in radial projection neuron migration
    in the developing cerebral cortex@
  fabio_hasPubmedId: '33102480'
...