---
res:
  bibo_abstract:
  - Collective cell migration offers a rich field of study for non-equilibrium physics
    and cellular biology, revealing phenomena such as glassy dynamics, pattern formation
    and active turbulence. However, how mechanical and chemical signalling are integrated
    at the cellular level to give rise to such collective behaviours remains unclear.
    We address this by focusing on the highly conserved phenomenon of spatiotemporal
    waves of density and extracellular signal-regulated kinase (ERK) activation, which
    appear both in vitro and in vivo during collective cell migration and wound healing.
    First, we propose a biophysical theory, backed by mechanical and optogenetic perturbation
    experiments, showing that patterns can be quantitatively explained by a mechanochemical
    coupling between active cellular tensions and the mechanosensitive ERK pathway.
    Next, we demonstrate how this biophysical mechanism can robustly induce long-ranged
    order and migration in a desired orientation, and we determine the theoretically
    optimal wavelength and period for inducing maximal migration towards free edges,
    which fits well with experimentally observed dynamics. We thereby provide a bridge
    between the biophysical origin of spatiotemporal instabilities and the design
    principles of robust and efficient long-ranged migration.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Daniel R
      foaf_name: Boocock, Daniel R
      foaf_surname: Boocock
      foaf_workInfoHomepage: http://www.librecat.org/personId=453AF628-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0002-1585-2631
  - foaf_Person:
      foaf_givenName: Naoya
      foaf_name: Hino, Naoya
      foaf_surname: Hino
  - foaf_Person:
      foaf_givenName: Natalia
      foaf_name: Ruzickova, Natalia
      foaf_surname: Ruzickova
      foaf_workInfoHomepage: http://www.librecat.org/personId=D2761128-D73D-11E9-A1BF-BA0DE6697425
  - foaf_Person:
      foaf_givenName: Tsuyoshi
      foaf_name: Hirashima, Tsuyoshi
      foaf_surname: Hirashima
  - foaf_Person:
      foaf_givenName: Edouard B
      foaf_name: Hannezo, Edouard B
      foaf_surname: Hannezo
      foaf_workInfoHomepage: http://www.librecat.org/personId=3A9DB764-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0001-6005-1561
  bibo_doi: 10.1038/s41567-020-01037-7
  bibo_volume: 17
  dct_date: 2021^xs_gYear
  dct_identifier:
  - UT:000573519500002
  dct_isPartOf:
  - http://id.crossref.org/issn/1745-2473
  - http://id.crossref.org/issn/1745-2481
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Theory of mechanochemical patterning and optimal migration in cell monolayers@
...