---
res:
  bibo_abstract:
  - The brain vasculature supplies neurons with glucose and oxygen, but little is
    known about how vascular plasticity contributes to brain function. Using longitudinal
    in vivo imaging, we report that a substantial proportion of blood vessels in the
    adult mouse brain sporadically occlude and regress. Their regression proceeds
    through sequential stages of blood-flow occlusion, endothelial cell collapse,
    relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels
    are found to be widespread in mouse, monkey and human brains. We further reveal
    that blood vessel regression cause a reduction of neuronal activity due to a dysfunction
    in mitochondrial metabolism and glutamate production. Our results elucidate the
    mechanism of vessel regression and its role in neuronal function in the adult
    brain.@eng
  bibo_authorlist:
  - foaf_Person:
      foaf_givenName: Xiaofei
      foaf_name: Gao, Xiaofei
      foaf_surname: Gao
  - foaf_Person:
      foaf_givenName: Jun-Liszt
      foaf_name: Li, Jun-Liszt
      foaf_surname: Li
  - foaf_Person:
      foaf_givenName: Xingjun
      foaf_name: Chen, Xingjun
      foaf_surname: Chen
  - foaf_Person:
      foaf_givenName: Bo
      foaf_name: Ci, Bo
      foaf_surname: Ci
  - foaf_Person:
      foaf_givenName: Fei
      foaf_name: Chen, Fei
      foaf_surname: Chen
  - foaf_Person:
      foaf_givenName: Nannan
      foaf_name: Lu, Nannan
      foaf_surname: Lu
  - foaf_Person:
      foaf_givenName: Bo
      foaf_name: Shen, Bo
      foaf_surname: Shen
  - foaf_Person:
      foaf_givenName: Lijun
      foaf_name: Zheng, Lijun
      foaf_surname: Zheng
  - foaf_Person:
      foaf_givenName: Jie-Min
      foaf_name: Jia, Jie-Min
      foaf_surname: Jia
  - foaf_Person:
      foaf_givenName: Yating
      foaf_name: Yi, Yating
      foaf_surname: Yi
  - foaf_Person:
      foaf_givenName: Shiwen
      foaf_name: Zhang, Shiwen
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Ying-Chao
      foaf_name: Shi, Ying-Chao
      foaf_surname: Shi
  - foaf_Person:
      foaf_givenName: Kaibin
      foaf_name: Shi, Kaibin
      foaf_surname: Shi
  - foaf_Person:
      foaf_givenName: Nicholas E
      foaf_name: Propson, Nicholas E
      foaf_surname: Propson
  - foaf_Person:
      foaf_givenName: Yubin
      foaf_name: Huang, Yubin
      foaf_surname: Huang
  - foaf_Person:
      foaf_givenName: Katherine
      foaf_name: Poinsatte, Katherine
      foaf_surname: Poinsatte
  - foaf_Person:
      foaf_givenName: Zhaohuan
      foaf_name: Zhang, Zhaohuan
      foaf_surname: Zhang
  - foaf_Person:
      foaf_givenName: Yuanlei
      foaf_name: Yue, Yuanlei
      foaf_surname: Yue
  - foaf_Person:
      foaf_givenName: Dale B
      foaf_name: Bosco, Dale B
      foaf_surname: Bosco
  - foaf_Person:
      foaf_givenName: Ying-mei
      foaf_name: Lu, Ying-mei
      foaf_surname: Lu
  - foaf_Person:
      foaf_givenName: Shi-bing
      foaf_name: Yang, Shi-bing
      foaf_surname: Yang
  - foaf_Person:
      foaf_givenName: Ralf H.
      foaf_name: Adams, Ralf H.
      foaf_surname: Adams
  - foaf_Person:
      foaf_givenName: Volkhard
      foaf_name: Lindner, Volkhard
      foaf_surname: Lindner
  - foaf_Person:
      foaf_givenName: Fen
      foaf_name: Huang, Fen
      foaf_surname: Huang
  - foaf_Person:
      foaf_givenName: Long-Jun
      foaf_name: Wu, Long-Jun
      foaf_surname: Wu
  - foaf_Person:
      foaf_givenName: Hui
      foaf_name: Zheng, Hui
      foaf_surname: Zheng
  - foaf_Person:
      foaf_givenName: Feng
      foaf_name: Han, Feng
      foaf_surname: Han
  - foaf_Person:
      foaf_givenName: Simon
      foaf_name: Hippenmeyer, Simon
      foaf_surname: Hippenmeyer
      foaf_workInfoHomepage: http://www.librecat.org/personId=37B36620-F248-11E8-B48F-1D18A9856A87
    orcid: 0000-0003-2279-1061
  - foaf_Person:
      foaf_givenName: Ann M.
      foaf_name: Stowe, Ann M.
      foaf_surname: Stowe
  - foaf_Person:
      foaf_givenName: Bo
      foaf_name: Peng, Bo
      foaf_surname: Peng
  - foaf_Person:
      foaf_givenName: Marta
      foaf_name: Margeta, Marta
      foaf_surname: Margeta
  - foaf_Person:
      foaf_givenName: Xiaoqun
      foaf_name: Wang, Xiaoqun
      foaf_surname: Wang
  - foaf_Person:
      foaf_givenName: Qiang
      foaf_name: Liu, Qiang
      foaf_surname: Liu
  - foaf_Person:
      foaf_givenName: Jakob
      foaf_name: Körbelin, Jakob
      foaf_surname: Körbelin
  - foaf_Person:
      foaf_givenName: Martin
      foaf_name: Trepel, Martin
      foaf_surname: Trepel
  - foaf_Person:
      foaf_givenName: Hui
      foaf_name: Lu, Hui
      foaf_surname: Lu
  - foaf_Person:
      foaf_givenName: Bo O.
      foaf_name: Zhou, Bo O.
      foaf_surname: Zhou
  - foaf_Person:
      foaf_givenName: Hu
      foaf_name: Zhao, Hu
      foaf_surname: Zhao
  - foaf_Person:
      foaf_givenName: Wenzhi
      foaf_name: Su, Wenzhi
      foaf_surname: Su
  - foaf_Person:
      foaf_givenName: Robert M.
      foaf_name: Bachoo, Robert M.
      foaf_surname: Bachoo
  - foaf_Person:
      foaf_givenName: Woo-ping
      foaf_name: Ge, Woo-ping
      foaf_surname: Ge
  bibo_doi: 10.1038/s41467-025-60308-0
  bibo_volume: 16
  dct_date: 2025^xs_gYear
  dct_identifier:
  - UT:001523450500035
  dct_isPartOf:
  - http://id.crossref.org/issn/2041-1723
  dct_language: eng
  dct_publisher: Springer Nature@
  dct_title: Reduction of neuronal activity mediated by blood-vessel regression in
    the brain@
...