Reduction of neuronal activity mediated by blood-vessel regression in the brain Gao, Xiaofei Li, Jun-Liszt Chen, Xingjun Ci, Bo Chen, Fei Lu, Nannan Shen, Bo Zheng, Lijun Jia, Jie-Min Yi, Yating Zhang, Shiwen Shi, Ying-Chao Shi, Kaibin Propson, Nicholas E Huang, Yubin Poinsatte, Katherine Zhang, Zhaohuan Yue, Yuanlei Bosco, Dale B Lu, Ying-mei Yang, Shi-bing Adams, Ralf H. Lindner, Volkhard Huang, Fen Wu, Long-Jun Zheng, Hui Han, Feng Hippenmeyer, Simon ; https://orcid.org/0000-0003-2279-1061 Stowe, Ann M. Peng, Bo Margeta, Marta Wang, Xiaoqun Liu, Qiang Körbelin, Jakob Trepel, Martin Lu, Hui Zhou, Bo O. Zhao, Hu Su, Wenzhi Bachoo, Robert M. Ge, Woo-ping ddc:570 The brain vasculature supplies neurons with glucose and oxygen, but little is known about how vascular plasticity contributes to brain function. Using longitudinal in vivo imaging, we report that a substantial proportion of blood vessels in the adult mouse brain sporadically occlude and regress. Their regression proceeds through sequential stages of blood-flow occlusion, endothelial cell collapse, relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels are found to be widespread in mouse, monkey and human brains. We further reveal that blood vessel regression cause a reduction of neuronal activity due to a dysfunction in mitochondrial metabolism and glutamate production. Our results elucidate the mechanism of vessel regression and its role in neuronal function in the adult brain. Springer Nature 2025 info:eu-repo/semantics/article doc-type:article text http://purl.org/coar/resource_type/c_2df8fbb1 https://research-explorer.ista.ac.at/record/8616 https://research-explorer.ista.ac.at/download/8616/19971 Gao X, Li J-L, Chen X, et al. Reduction of neuronal activity mediated by blood-vessel regression in the brain. <i>Nature Communications</i>. 2025;16. doi:<a href="https://doi.org/10.1038/s41467-025-60308-0">10.1038/s41467-025-60308-0</a> eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41467-025-60308-0 info:eu-repo/semantics/altIdentifier/e-issn/2041-1723 info:eu-repo/semantics/altIdentifier/wos/001523450500035 info:eu-repo/semantics/openAccess