---
DOAJ_listed: '1'
OA_place: publisher
OA_type: gold
_id: '8616'
abstract:
- lang: eng
  text: The brain vasculature supplies neurons with glucose and oxygen, but little
    is known about how vascular plasticity contributes to brain function. Using longitudinal
    in vivo imaging, we report that a substantial proportion of blood vessels in the
    adult mouse brain sporadically occlude and regress. Their regression proceeds
    through sequential stages of blood-flow occlusion, endothelial cell collapse,
    relocation or loss of pericytes, and retraction of glial endfeet. Regressing vessels
    are found to be widespread in mouse, monkey and human brains. We further reveal
    that blood vessel regression cause a reduction of neuronal activity due to a dysfunction
    in mitochondrial metabolism and glutamate production. Our results elucidate the
    mechanism of vessel regression and its role in neuronal function in the adult
    brain.
acknowledgement: 'The project was initiated in the Jan lab at UCSF. We thank Lily
  Jan and Yuh-Nung Jan’s generous support. We thank Liqun Luo’s lab for providing
  MADM-7 mice and Rolf A Brekken for VEGF-antibodies.  Drs. Yuanquan Song (UPenn),
  Zhaozhu Hu (JHU), Ji Hu (ShanghaiTech), Yang Xiang (U. Mass), Hao Wang (Zhejiang
  U.) and Ruikang Wang (U. Washington) for critical input, colleagues at Children’s
  Research Institute, Departments of Neuroscience, Neurology and Neurotherapeutics,
  Pediatrics from UT Southwestern, and colleagues from the Jan lab for discussion.
  Dr. Bridget Samuels, Sean Morrison (UT Southwestern), and Nannan Lu (Zhejiang U.)
  for critical reading. We acknowledge the assistance of the CIBR Imaging core. We
  also thank UT Southwestern Live Cell Imaging Facility, a Shared Resource of the
  Harold C. Simmons Cancer Center, supported in part by an NCI Cancer Center Support
  Grant, P30 CA142543K. This work is supported by CIBR funds and the American Heart
  Association AWRP Summer 2016 Innovative Research Grant (17IRG33410377) to W-P.G.;
  National Natural Science Foundation of China (No.81370031) to Z.Z.;National Key
  Research and Development Program of China (2016YFE0125400)to F.H.;National Natural
  Science Foundations of China (No. 81473202) to Y.L.; National Natural Science Foundation
  of China (No.31600839) and Shenzhen Science and Technology Research Program (JCYJ20170818163320865)
  to B.P.; National Natural Science Foundation of China (No. 31800864) and Westlake
  University start-up funds to J-M. J. NIH R01NS088627 to W.L.J.; NIH: R01 AG020670
  and RF1AG054111 to H.Z.; R01 NS088555 to A.M.S., and European Research Council No.725780
  to S.H.;W-P.G. was a recipient of Bugher-American Heart Association Dan Adams Thinking
  Outside the Box Award.'
article_number: '5840'
article_processing_charge: Yes
article_type: original
author:
- first_name: Xiaofei
  full_name: Gao, Xiaofei
  last_name: Gao
- first_name: Jun-Liszt
  full_name: Li, Jun-Liszt
  last_name: Li
- first_name: Xingjun
  full_name: Chen, Xingjun
  last_name: Chen
- first_name: Bo
  full_name: Ci, Bo
  last_name: Ci
- first_name: Fei
  full_name: Chen, Fei
  last_name: Chen
- first_name: Nannan
  full_name: Lu, Nannan
  last_name: Lu
- first_name: Bo
  full_name: Shen, Bo
  last_name: Shen
- first_name: Lijun
  full_name: Zheng, Lijun
  last_name: Zheng
- first_name: Jie-Min
  full_name: Jia, Jie-Min
  last_name: Jia
- first_name: Yating
  full_name: Yi, Yating
  last_name: Yi
- first_name: Shiwen
  full_name: Zhang, Shiwen
  last_name: Zhang
- first_name: Ying-Chao
  full_name: Shi, Ying-Chao
  last_name: Shi
- first_name: Kaibin
  full_name: Shi, Kaibin
  last_name: Shi
- first_name: Nicholas E
  full_name: Propson, Nicholas E
  last_name: Propson
- first_name: Yubin
  full_name: Huang, Yubin
  last_name: Huang
- first_name: Katherine
  full_name: Poinsatte, Katherine
  last_name: Poinsatte
- first_name: Zhaohuan
  full_name: Zhang, Zhaohuan
  last_name: Zhang
- first_name: Yuanlei
  full_name: Yue, Yuanlei
  last_name: Yue
- first_name: Dale B
  full_name: Bosco, Dale B
  last_name: Bosco
- first_name: Ying-mei
  full_name: Lu, Ying-mei
  last_name: Lu
- first_name: Shi-bing
  full_name: Yang, Shi-bing
  last_name: Yang
- first_name: Ralf H.
  full_name: Adams, Ralf H.
  last_name: Adams
- first_name: Volkhard
  full_name: Lindner, Volkhard
  last_name: Lindner
- first_name: Fen
  full_name: Huang, Fen
  last_name: Huang
- first_name: Long-Jun
  full_name: Wu, Long-Jun
  last_name: Wu
- first_name: Hui
  full_name: Zheng, Hui
  last_name: Zheng
- first_name: Feng
  full_name: Han, Feng
  last_name: Han
- first_name: Simon
  full_name: Hippenmeyer, Simon
  id: 37B36620-F248-11E8-B48F-1D18A9856A87
  last_name: Hippenmeyer
  orcid: 0000-0003-2279-1061
- first_name: Ann M.
  full_name: Stowe, Ann M.
  last_name: Stowe
- first_name: Bo
  full_name: Peng, Bo
  last_name: Peng
- first_name: Marta
  full_name: Margeta, Marta
  last_name: Margeta
- first_name: Xiaoqun
  full_name: Wang, Xiaoqun
  last_name: Wang
- first_name: Qiang
  full_name: Liu, Qiang
  last_name: Liu
- first_name: Jakob
  full_name: Körbelin, Jakob
  last_name: Körbelin
- first_name: Martin
  full_name: Trepel, Martin
  last_name: Trepel
- first_name: Hui
  full_name: Lu, Hui
  last_name: Lu
- first_name: Bo O.
  full_name: Zhou, Bo O.
  last_name: Zhou
- first_name: Hu
  full_name: Zhao, Hu
  last_name: Zhao
- first_name: Wenzhi
  full_name: Su, Wenzhi
  last_name: Su
- first_name: Robert M.
  full_name: Bachoo, Robert M.
  last_name: Bachoo
- first_name: Woo-ping
  full_name: Ge, Woo-ping
  last_name: Ge
citation:
  ama: Gao X, Li J-L, Chen X, et al. Reduction of neuronal activity mediated by blood-vessel
    regression in the brain. <i>Nature Communications</i>. 2025;16. doi:<a href="https://doi.org/10.1038/s41467-025-60308-0">10.1038/s41467-025-60308-0</a>
  apa: Gao, X., Li, J.-L., Chen, X., Ci, B., Chen, F., Lu, N., … Ge, W. (2025). Reduction
    of neuronal activity mediated by blood-vessel regression in the brain. <i>Nature
    Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-025-60308-0">https://doi.org/10.1038/s41467-025-60308-0</a>
  chicago: Gao, Xiaofei, Jun-Liszt Li, Xingjun Chen, Bo Ci, Fei Chen, Nannan Lu, Bo
    Shen, et al. “Reduction of Neuronal Activity Mediated by Blood-Vessel Regression
    in the Brain.” <i>Nature Communications</i>. Springer Nature, 2025. <a href="https://doi.org/10.1038/s41467-025-60308-0">https://doi.org/10.1038/s41467-025-60308-0</a>.
  ieee: X. Gao <i>et al.</i>, “Reduction of neuronal activity mediated by blood-vessel
    regression in the brain,” <i>Nature Communications</i>, vol. 16. Springer Nature,
    2025.
  ista: Gao X, Li J-L, Chen X, Ci B, Chen F, Lu N, Shen B, Zheng L, Jia J-M, Yi Y,
    Zhang S, Shi Y-C, Shi K, Propson NE, Huang Y, Poinsatte K, Zhang Z, Yue Y, Bosco
    DB, Lu Y, Yang S, Adams RH, Lindner V, Huang F, Wu L-J, Zheng H, Han F, Hippenmeyer
    S, Stowe AM, Peng B, Margeta M, Wang X, Liu Q, Körbelin J, Trepel M, Lu H, Zhou
    BO, Zhao H, Su W, Bachoo RM, Ge W. 2025. Reduction of neuronal activity mediated
    by blood-vessel regression in the brain. Nature Communications. 16, 5840.
  mla: Gao, Xiaofei, et al. “Reduction of Neuronal Activity Mediated by Blood-Vessel
    Regression in the Brain.” <i>Nature Communications</i>, vol. 16, 5840, Springer
    Nature, 2025, doi:<a href="https://doi.org/10.1038/s41467-025-60308-0">10.1038/s41467-025-60308-0</a>.
  short: X. Gao, J.-L. Li, X. Chen, B. Ci, F. Chen, N. Lu, B. Shen, L. Zheng, J.-M.
    Jia, Y. Yi, S. Zhang, Y.-C. Shi, K. Shi, N.E. Propson, Y. Huang, K. Poinsatte,
    Z. Zhang, Y. Yue, D.B. Bosco, Y. Lu, S. Yang, R.H. Adams, V. Lindner, F. Huang,
    L.-J. Wu, H. Zheng, F. Han, S. Hippenmeyer, A.M. Stowe, B. Peng, M. Margeta, X.
    Wang, Q. Liu, J. Körbelin, M. Trepel, H. Lu, B.O. Zhou, H. Zhao, W. Su, R.M. Bachoo,
    W. Ge, Nature Communications 16 (2025).
date_created: 2020-10-06T08:58:59Z
date_published: 2025-07-01T00:00:00Z
date_updated: 2025-09-04T07:08:37Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1038/s41467-025-60308-0
ec_funded: 1
external_id:
  isi:
  - '001523450500035'
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has_accepted_license: '1'
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language:
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month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 260018B0-B435-11E9-9278-68D0E5697425
  call_identifier: H2020
  grant_number: '725780'
  name: Principles of Neural Stem Cell Lineage Progression in Cerebral Cortex Development
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Reduction of neuronal activity mediated by blood-vessel regression in the brain
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  short: CC BY-NC-ND (4.0)
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...