---
_id: '8669'
abstract:
- lang: eng
  text: Pancreatic islets play an essential role in regulating blood glucose level.
    Although the molecular pathways underlying islet cell differentiation are beginning
    to be resolved, the cellular basis of islet morphogenesis and fate allocation
    remain unclear. By combining unbiased and targeted lineage tracing, we address
    the events leading to islet formation in the mouse. From the statistical analysis
    of clones induced at multiple embryonic timepoints, here we show that, during
    the secondary transition, islet formation involves the aggregation of multiple
    equipotent endocrine progenitors that transition from a phase of stochastic amplification
    by cell division into a phase of sublineage restriction and limited islet fission.
    Together, these results explain quantitatively the heterogeneous size distribution
    and degree of polyclonality of maturing islets, as well as dispersion of progenitors
    within and between islets. Further, our results show that, during the secondary
    transition, α- and β-cells are generated in a contemporary manner. Together, these
    findings provide insight into the cellular basis of islet development.
article_number: '5037'
article_processing_charge: No
article_type: original
author:
- first_name: Magdalena K.
  full_name: Sznurkowska, Magdalena K.
  last_name: Sznurkowska
- first_name: Edouard B
  full_name: Hannezo, Edouard B
  id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
  last_name: Hannezo
  orcid: 0000-0001-6005-1561
- first_name: Roberta
  full_name: Azzarelli, Roberta
  last_name: Azzarelli
- first_name: Lemonia
  full_name: Chatzeli, Lemonia
  last_name: Chatzeli
- first_name: Tatsuro
  full_name: Ikeda, Tatsuro
  last_name: Ikeda
- first_name: Shosei
  full_name: Yoshida, Shosei
  last_name: Yoshida
- first_name: Anna
  full_name: Philpott, Anna
  last_name: Philpott
- first_name: Benjamin D
  full_name: Simons, Benjamin D
  last_name: Simons
citation:
  ama: Sznurkowska MK, Hannezo EB, Azzarelli R, et al. Tracing the cellular basis
    of islet specification in mouse pancreas. <i>Nature Communications</i>. 2020;11.
    doi:<a href="https://doi.org/10.1038/s41467-020-18837-3">10.1038/s41467-020-18837-3</a>
  apa: Sznurkowska, M. K., Hannezo, E. B., Azzarelli, R., Chatzeli, L., Ikeda, T.,
    Yoshida, S., … Simons, B. D. (2020). Tracing the cellular basis of islet specification
    in mouse pancreas. <i>Nature Communications</i>. Springer Nature. <a href="https://doi.org/10.1038/s41467-020-18837-3">https://doi.org/10.1038/s41467-020-18837-3</a>
  chicago: Sznurkowska, Magdalena K., Edouard B Hannezo, Roberta Azzarelli, Lemonia
    Chatzeli, Tatsuro Ikeda, Shosei Yoshida, Anna Philpott, and Benjamin D Simons.
    “Tracing the Cellular Basis of Islet Specification in Mouse Pancreas.” <i>Nature
    Communications</i>. Springer Nature, 2020. <a href="https://doi.org/10.1038/s41467-020-18837-3">https://doi.org/10.1038/s41467-020-18837-3</a>.
  ieee: M. K. Sznurkowska <i>et al.</i>, “Tracing the cellular basis of islet specification
    in mouse pancreas,” <i>Nature Communications</i>, vol. 11. Springer Nature, 2020.
  ista: Sznurkowska MK, Hannezo EB, Azzarelli R, Chatzeli L, Ikeda T, Yoshida S, Philpott
    A, Simons BD. 2020. Tracing the cellular basis of islet specification in mouse
    pancreas. Nature Communications. 11, 5037.
  mla: Sznurkowska, Magdalena K., et al. “Tracing the Cellular Basis of Islet Specification
    in Mouse Pancreas.” <i>Nature Communications</i>, vol. 11, 5037, Springer Nature,
    2020, doi:<a href="https://doi.org/10.1038/s41467-020-18837-3">10.1038/s41467-020-18837-3</a>.
  short: M.K. Sznurkowska, E.B. Hannezo, R. Azzarelli, L. Chatzeli, T. Ikeda, S. Yoshida,
    A. Philpott, B.D. Simons, Nature Communications 11 (2020).
date_created: 2020-10-18T22:01:35Z
date_published: 2020-10-07T00:00:00Z
date_updated: 2026-04-02T14:29:58Z
day: '07'
ddc:
- '570'
department:
- _id: EdHa
doi: 10.1038/s41467-020-18837-3
external_id:
  isi:
  - '000577244600003'
  pmid:
  - '33028844'
file:
- access_level: open_access
  checksum: 0ecc0eab72d2d50694852579611a6624
  content_type: application/pdf
  creator: dernst
  date_created: 2020-10-19T11:27:46Z
  date_updated: 2020-10-19T11:27:46Z
  file_id: '8677'
  file_name: 2020_NatureComm_Sznurkowska.pdf
  file_size: 5540540
  relation: main_file
  success: 1
file_date_updated: 2020-10-19T11:27:46Z
has_accepted_license: '1'
intvolume: '        11'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
publication: Nature Communications
publication_identifier:
  eissn:
  - 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tracing the cellular basis of islet specification in mouse pancreas
tmp:
  image: /images/cc_by.png
  legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
  name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
  short: CC BY (4.0)
type: journal_article
user_id: ba8df636-2132-11f1-aed0-ed93e2281fdd
volume: 11
year: '2020'
...